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Can a dysfunctional T-cell gene signature predict nonresponse to PD-1 blockade in non-small cell lung cancer?

作者信息

Taniguchi Hirokazu, Ashizawa Kazuto, Mukae Hiroshi

机构信息

Clinical Oncology Center, Nagasaki University Hospital, Nagasaki, Japan.

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

出版信息

Transl Lung Cancer Res. 2024 Aug 31;13(8):2091-2094. doi: 10.21037/tlcr-24-286. Epub 2024 Jul 31.

DOI:10.21037/tlcr-24-286
PMID:39263015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11384482/
Abstract
摘要

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本文引用的文献

1
A Dysfunctional T-cell Gene Signature for Predicting Nonresponse to PD-1 Blockade in Non-small Cell Lung Cancer That Is Suitable for Routine Clinical Diagnostics.一种预测非小细胞肺癌对 PD-1 阻断无反应的功能失调 T 细胞基因特征,适用于常规临床诊断。
Clin Cancer Res. 2024 Feb 16;30(4):814-823. doi: 10.1158/1078-0432.CCR-23-1061.
2
The cancer-immunity cycle: Indication, genotype, and immunotype.癌症免疫周期:指征、基因型和免疫型。
Immunity. 2023 Oct 10;56(10):2188-2205. doi: 10.1016/j.immuni.2023.09.011.
3
Immune checkpoint therapy and response biomarkers in non-small-cell lung cancer: Serum NY-ESO-1 and XAGE1 antibody as predictive and monitoring markers.
免疫检查点治疗和非小细胞肺癌的反应生物标志物:血清 NY-ESO-1 和 XAGE1 抗体作为预测和监测标志物。
Adv Clin Chem. 2023;112:155-204. doi: 10.1016/bs.acc.2022.09.004. Epub 2022 Nov 17.
4
Five-Year Outcomes With Pembrolizumab Versus Chemotherapy as First-Line Therapy in Patients With Non-Small-Cell Lung Cancer and Programmed Death Ligand-1 Tumor Proportion Score ≥ 1% in the KEYNOTE-042 Study.KEYNOTE-042 研究中,PD-L1 肿瘤比例分数≥1%的非小细胞肺癌患者中,帕博利珠单抗对比化疗作为一线治疗的 5 年总生存期结果。
J Clin Oncol. 2023 Apr 10;41(11):1986-1991. doi: 10.1200/JCO.21.02885. Epub 2022 Oct 28.
5
PD-1T TILs as a Predictive Biomarker for Clinical Benefit to PD-1 Blockade in Patients with Advanced NSCLC.PD-1T TILs 作为晚期 NSCLC 患者接受 PD-1 阻断治疗临床获益的预测性生物标志物。
Clin Cancer Res. 2022 Nov 14;28(22):4893-4906. doi: 10.1158/1078-0432.CCR-22-0992.
6
First-Line Immunotherapy for Non-Small-Cell Lung Cancer.非小细胞肺癌的一线免疫治疗。
J Clin Oncol. 2022 Feb 20;40(6):586-597. doi: 10.1200/JCO.21.01497. Epub 2022 Jan 5.
7
Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50.帕博利珠单抗对比化疗用于 PD-L1 肿瘤比例分数≥50%的转移性非小细胞肺癌的 5 年结果。
J Clin Oncol. 2021 Jul 20;39(21):2339-2349. doi: 10.1200/JCO.21.00174. Epub 2021 Apr 19.
8
Predictors of Response, Progression-Free Survival, and Overall Survival in Patients With Lung Cancer Treated With Immune Checkpoint Inhibitors.免疫检查点抑制剂治疗肺癌患者的反应、无进展生存期和总生存期的预测因素。
J Thorac Oncol. 2021 Jul;16(7):1086-1098. doi: 10.1016/j.jtho.2021.03.017. Epub 2021 Apr 9.
9
Five-Year Outcomes From the Randomized, Phase III Trials CheckMate 017 and 057: Nivolumab Versus Docetaxel in Previously Treated Non-Small-Cell Lung Cancer.CheckMate 017 和 057 随机、III 期临床试验的 5 年结果:纳武利尤单抗对比多西他赛用于先前治疗的非小细胞肺癌。
J Clin Oncol. 2021 Mar 1;39(7):723-733. doi: 10.1200/JCO.20.01605. Epub 2021 Jan 15.
10
The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker.肿瘤突变负荷作为免疫治疗生物标志物面临的挑战。
Cancer Cell. 2021 Feb 8;39(2):154-173. doi: 10.1016/j.ccell.2020.10.001. Epub 2020 Oct 29.