Xie Long, Mao Tianshi, Gao Qun, Pan Yi, Yang Zhifei, Qu Xinyan, Feng Ruli, Xia Junyan, Lin Qian, Wan Jie
Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100029, China.
Department of Cardiology, Dongfang Hospital Beijing University of Chinese Medicine, Beijing, 100029, China.
Heliyon. 2024 Aug 19;10(17):e36327. doi: 10.1016/j.heliyon.2024.e36327. eCollection 2024 Sep 15.
This study utilized network meta-analysis (NMA) to compare the efficacy of five commonly used traditional Chinese medicine monomers in reducing intimal hyperproliferation in arterial balloon injury models.
Relevant literature up to January 2024 was systematically retrieved from seven major databases. The intima-to-media (I/M) ratio was chosen as the primary outcome measure. The risk of bias in animal studies was assessed using the SYstematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Statistical analysis was conducted using Stata 17 software.
A total of 43 studies were included in this meta-analysis. NMA results showed that in the rat model, compared to the control group, GS (SMD: 0.99, 95%CI: 1.25 to -0.73), ASIV (SMD: 1.16, 95%CI: 1.65 to -0.67), TMP (SMD: 0.68, 95%CI: 1.31 to -0.05), and TPNS (SMD: 1.36, 95%CI: 1.91 to -0.80) exhibited inhibitory effects on postoperative intimal hyperproliferation, reducing the I/M ratio. In the rabbit model, compared to the control group, TPNS (SMD: 1.23, 95%CI: 1.97 to -0.49) inhibited postoperative intimal hyperproliferation and reduced the I/M ratio. Superiority ranking analysis suggested that total notoginseng saponin (TPNS) might be the most effective traditional Chinese medicine monomer in reducing intimal hyperproliferation in arterial balloon injury models, lowering the I/M ratio.
NMA indicates that traditional Chinese medicine monomers can effectively reduce postoperative intimal hyperproliferation in arterial balloon injury models, lowering the I/M ratio, with TPNS showing optimal efficacy. However, the research on TIIA is insufficient, and the limited sample size may affect the robustness of the results. Furthermore, the majority of research on traditional Chinese medicine monomers is currently limited to the experimental stage, lacking further clinical validation. Conducting standardized animal experiments and reporting their findings can enhance the quality of evidence from animal studies, laying the foundation for future clinical trials.
本研究采用网络荟萃分析（NMA）比较五种常用中药单体在动脉球囊损伤模型中减少内膜增生的疗效。
系统检索截至2024年1月的七个主要数据库中的相关文献。选择内膜中膜比（I/M）作为主要结局指标。使用实验动物系统评价中心（SYRCLE）工具评估动物研究中的偏倚风险。使用Stata 17软件进行统计分析。
本荟萃分析共纳入43项研究。NMA结果显示，在大鼠模型中，与对照组相比，人参皂苷（GS，标准化均值差：0.99，95%置信区间：1.25至-0.73）、黄芪甲苷（ASIV，标准化均值差：1.16，95%置信区间：1.65至-0.67）、川芎嗪（TMP，标准化均值差：0.68，95%置信区间：1.31至-0.05）和三七总皂苷（TPNS，标准化均值差：1.36，95%置信区间：1.91至-0.80）对术后内膜增生具有抑制作用，降低了I/M比。在兔模型中，与对照组相比，TPNS（标准化均值差：1.23，95%置信区间：1.97至-0.49）抑制术后内膜增生并降低了I/M比。优势排序分析表明，三七总皂苷（TPNS）可能是在动脉球囊损伤模型中减少内膜增生、降低I/M比最有效的中药单体。
NMA表明中药单体可有效降低动脉球囊损伤模型术后内膜增生，降低I/M比，其中TPNS疗效最佳。然而，对丹参酮IIA的研究不足，样本量有限可能影响结果的稳健性。此外，目前大多数关于中药单体的研究仅限于实验阶段，缺乏进一步的临床验证。开展标准化动物实验并报告结果可提高动物研究证据的质量，为未来的临床试验奠定基础。
