Zhou Dan, Xue Jing, Sun Yaqiong, Zhu Liling, Zhao Ming, Cui Meimei, Zhang Min, Jia Jingjing, Luo Limei
Maternal and Child Health Development Research Center, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China.
School of Public Health, Jiamusi University, Jiamusi, Heilongjiang, China.
Heliyon. 2024 Aug 18;10(17):e35736. doi: 10.1016/j.heliyon.2024.e35736. eCollection 2024 Sep 15.
Data on the patterns of single and multiple HPV infections are largely limited to small size studies, and the regional difference have not been systematically examined.
A literature search was conducted using PubMed, Embase, and Web of Science databases up to Sept 22, 2023. The pooled prevalence of HPV infection were calculated using random-effects meta-analysis. Subgroup analysis was used to explore the heterogeneity, and publication bias was evaluated by Egger's test and Begg's test.
There were 121 studies included with 1,682,422 participants. Globally, the most common genotypes of single HPV infection were HPV16 (7.05 %), 18 (1.94 %), 52 (1.93 %), 58 (1.68 %), and 31 (1.53 %), as well as HPV 16 (4.91 %), 31 (2.68 %), 52 (2.20 %), 51 (1.99 %), and 18 (1.96 %) in multiple HPV infections. Apart from HPV16 and 18, HPV52 and 58 were common in Asia, HPV31 and 51 was in Europe, North and South America, and HPV35 and 45 were in Africa. The prevalence of HPV infection among different age groups (<30, 30-50, >50 years age groups) was 20.93 %, 16.27 %, and 18.69 %, respectively. The single HPV infection prevalence in the No-ILs, LSILs, HSILs, and cervical cancer groups were 16.17 %, 51.60 %, 57.12 %, and 62.88 %, respectively, as well as in multiple infections were 5.09 %, 30.93 %, 32.86 %, and 21.26.
Developing local HPV vaccines is necessary based on the HPV infection pattern. It is essential to educate young women to get vaccinated and encourage elderly women to have regular cervical cancer screenings to reduce the danger of cervical cancer.
关于单一和多重人乳头瘤病毒（HPV）感染模式的数据在很大程度上仅限于小规模研究，且尚未对地区差异进行系统研究。
使用PubMed、Embase和Web of Science数据库进行文献检索，检索截至2023年9月22日的文献。采用随机效应荟萃分析计算HPV感染的合并患病率。亚组分析用于探讨异质性，并通过Egger检验和Begg检验评估发表偏倚。
共纳入121项研究，涉及1,682,422名参与者。在全球范围内，单一HPV感染最常见的基因型为HPV16（7.05%）、18（1.94%）、52（1.93%）、58（1.68%）和31（1.53%），多重HPV感染中最常见的基因型为HPV 16（4.91%）、31（2.68%）、52（2.20%）、51（1.99%）和18（1.96%）。除HPV16和18外，HPV52和58在亚洲常见，HPV31和51在欧洲、北美洲和南美洲常见，HPV35和45在非洲常见。不同年龄组（<30岁、30 - 50岁、>50岁年龄组）的HPV感染患病率分别为20.93%、16.27%和18.69%。在无上皮内病变（No-ILs）、低度鳞状上皮内病变（LSILs）、高度鳞状上皮内病变（HSILs）和宫颈癌组中，单一HPV感染的患病率分别为16.17%、51.60%、57.12%和62.88%，多重感染的患病率分别为5.09%、30.93%、32.86%和21.26%。
基于HPV感染模式开发本地HPV疫苗是必要的。对年轻女性进行疫苗接种教育并鼓励老年女性定期进行宫颈癌筛查以降低宫颈癌风险至关重要。
