Na Jing, Li Ya, Wang Jun, Wang Xinyou, Lu JunLing, Han Shichao
Department of Gynecology and Obstetrics, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Front Microbiol. 2023 Jul 28;14:1220522. doi: 10.3389/fmicb.2023.1220522. eCollection 2023.
Cervical carcinoma is the fourth female malignant tumor in the world, and the persistent infection of high-risk human papillomavirus (HPV) is recognized as the most common cause. This article studies the correlation between multiple HPV infections and the occurrence, development, and prognosis of cervical cancer in order to provide more references for clinical diagnosis and treatment. We conducted a retrospective analysis of the clinical data of 400 cervical carcinoma patients admitted to our hospital from 2015 to 2023. The collected patient data include age, HPV infection status, tumor size and morphology, local infiltration depth, diagnostic staging, surgical approach, vascular cancer thrombus status, lymph node status, and postoperative HPV follow-up status. We use SPSS statistical software for data analysis. Our research shows that the high-risk age group for cervical carcinoma is concentrated between 41 and 60 years old, which is basically consistent with the age range of the high incidence of HPV infection. In the statistics for HPV infection types, ~67.7% of patients are single HPV-infected, 25.29% are double infected, and 7.00% are infected with three or more types of HPV. Among the multiple HPV infections, most of the patients are younger than 40 years old and older than 70 years old, with double infection accounting for the majority. The top five HPV subtypes with high detection rates belong to high-risk subtypes, which are the HPV16, 18, 58, 33, and 52 subtypes, respectively. There was no significant relationship between multiple HPV infections and cervical cancer stage, lesion size, pathological tissue type, tissue differentiation degree/vascular cancer thrombus, and lymph node metastasis, and there was no significant difference in the results between the groups. In summary, multiple types of HPV infection in the cervix are common. We found that multiple infections, mainly HPV16, are closely related to cervical cancer. For the HPV16, 18, 58, 33, and 52 subtypes of infection, especially for patients younger than 40 years old and older than 70 years old, priority should be given to prevention and treatment. The relationship between multiple HPV infections and the progression and prognosis of cervical carcinoma requires further research, which could better guide cancer prevention and treatment.
宫颈癌是全球第四大女性恶性肿瘤，高危型人乳头瘤病毒（HPV）的持续感染被认为是其最常见病因。本文研究多重HPV感染与宫颈癌发生、发展及预后的相关性，以便为临床诊断和治疗提供更多参考。我们对2015年至2023年我院收治的400例宫颈癌患者的临床资料进行回顾性分析。收集的患者数据包括年龄、HPV感染状况、肿瘤大小及形态、局部浸润深度、诊断分期、手术方式、血管癌栓状况、淋巴结状况以及术后HPV随访状况。我们使用SPSS统计软件进行数据分析。研究表明，宫颈癌的高危年龄组集中在41至60岁之间，这与HPV感染的高发年龄范围基本一致。在HPV感染类型统计中，约67.7%的患者为单一HPV感染，25.29%为双重感染，7.00%为三种及以上类型的HPV感染。在多重HPV感染中，大多数患者年龄小于40岁或大于70岁，以双重感染为主。检测率居前五位的HPV亚型属于高危亚型，分别为HPV16、18、58、33和52亚型。多重HPV感染与宫颈癌分期、病灶大小、病理组织类型、组织分化程度/血管癌栓及淋巴结转移之间无显著关系，组间结果无显著差异。综上所述，宫颈多重HPV感染较为常见。我们发现多重感染，主要是HPV16感染，与宫颈癌密切相关。对于HPV16、18、58、33和52亚型感染，尤其是年龄小于40岁和大于70岁的患者，应优先进行防治。多重HPV感染与宫颈癌进展及预后的关系有待进一步研究，以便更好地指导癌症防治。
