芳香维甲酸对大鼠乳腺癌发生的影响。
The effects of arotinoids on rat mammary carcinogenesis.
作者信息
Hartmann H R, Bollag W
出版信息
Cancer Chemother Pharmacol. 1985;15(2):141-3. doi: 10.1007/BF00257524.
PMID:3926332
Abstract
The influence of two retinoids, Ro 13-6298, an arotinoid ethyl ester, and Ro 15-1570, an arotinoid ethyl sulfone, on rat mammary carcinogenesis was investigated. Mammary carcinomas were induced by oral administration of 15 mg dimethylbenz(a)anthracene (DMBA) to 50-day-old female Sprague-Dawley rats. Oral administration of the two retinoids significantly inhibited the development of tumors. The number and volume of mammary neoplasms were influenced in a dose-dependent manner.
摘要
研究了两种维甲酸，即芳维甲酸乙酯Ro 13-6298和芳维甲酸乙酯砜Ro 15-1570对大鼠乳腺癌发生的影响。通过给50日龄的雌性斯普拉格-道利大鼠口服15毫克二甲基苯并(a)蒽（DMBA）诱导乳腺癌。口服这两种维甲酸显著抑制了肿瘤的发展。乳腺肿瘤的数量和体积受到剂量依赖性的影响。
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