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Prostaglandin H synthase-dependent epoxidation of aflatoxin B1.

作者信息

Battista J R, Marnett L J

出版信息

Carcinogenesis. 1985 Aug;6(8):1227-9. doi: 10.1093/carcin/6.8.1227.

DOI:10.1093/carcin/6.8.1227
PMID:3926338
Abstract

This report demonstrates that aflatoxin B1 (AFB1) is cooxidized by prostaglandin H (PGH) synthase to form 2,3-dihydro-2,3-epoxy-aflatoxin B1 oxide. Using ram seminal vesicle microsomes as a source of PGH synthase, our results demonstrate that AFB1 is converted to a mutagen during arachidonate turnover that we identify as the epoxide by isolating adducts formed to DNA. The efficiency of AFB1 epoxidation by PGH synthase is assessed and compared with mixed-function oxidase-dependent metabolic activation of this compound.

摘要

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