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嵌入细胞中的光热金纳米颗粒中等离激元共振的有限元建模

Finite element modeling of plasmonic resonances in photothermal gold nanoparticles embedded in cells.

作者信息

París Ogáyar Marina, López-Méndez Rosalía, Figueruelo-Campanero Ignacio, Muñoz-Ortiz Tamara, Wilhelm Claire, Jaque Daniel, Espinosa Ana, Serrano Aida

机构信息

Instituto de Cerámica y Vidrio (ICV-CSIC) C/Kelsen, 5 Madrid 28049 Spain

IMDEA Nanociencia C/Faraday, 9 Madrid 28049 Spain.

出版信息

Nanoscale Adv. 2024 Jul 10;6(18):4635-4646. doi: 10.1039/d4na00247d. eCollection 2024 Sep 10.

DOI:10.1039/d4na00247d
PMID:39263395
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11386126/
Abstract

The use of plasmonic nanoparticles in performing photothermal treatments in cancer cells requires a full knowledge about their optical properties. The surface plasmon resonance is easily foreseen and measurable in colloidal suspensions, however it can be strongly modified when located inside cells. Assessing the optical behavior of plasmonic nanoparticles in cells is essential for an efficient and controlled treatment. This requires the combination of experimental data and computational models to understand the mechanisms that cause the change in their optical response. In this work, we investigate the plasmonic response of Au nanospheres (AuNSs) internalized into cancer cells (MCF-7). Experimental data are compared to the simulations provided by a 3D model based on a finite element method. We demonstrate the impact of physical parameters such as the type of NS assembly, the surrounding medium and the interparticle gap, in the photothermal efficiency of AuNSs. Results open the avenue to predict, by numerical calculations, the optical properties of plasmonic nanoparticles inside cells to minimize treatment costs and times in photothermal therapies.

摘要

在癌细胞中使用等离子体纳米颗粒进行光热治疗需要全面了解其光学性质。表面等离子体共振在胶体悬浮液中很容易预见和测量，然而当它位于细胞内部时，其性质会发生强烈改变。评估等离子体纳米颗粒在细胞中的光学行为对于高效且可控的治疗至关重要。这需要结合实验数据和计算模型来理解导致其光学响应变化的机制。在这项工作中，我们研究了内化到癌细胞（MCF - 7）中的金纳米球（AuNSs）的等离子体响应。将实验数据与基于有限元方法的三维模型提供的模拟结果进行比较。我们展示了诸如纳米球组装类型、周围介质和颗粒间间隙等物理参数对金纳米球光热效率的影响。研究结果为通过数值计算预测细胞内等离子体纳米颗粒的光学性质开辟了道路，以尽量减少光热疗法的治疗成本和时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6939/11386126/e40cd8cb8be4/d4na00247d-f9.jpg
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