Haikal Rana R, El Salakawy Noha, Ibrahim Alaa, Ali Shaimaa L, Mamdouh Wael
Department of Chemistry, School of Sciences and Engineering, The American University in Cairo (AUC) AUC Avenue, P. O. Box 74 New Cairo 11835 Egypt
Nanoscale Adv. 2024 Jul 17;6(18):4664-4671. doi: 10.1039/d4na00519h. eCollection 2024 Sep 10.
Antimicrobial resistance (AMR) has become an immense threat to public health leading to an urgent need for development of new technologies to tackle such a challenge. Plant-based drugs, specifically essential oils (EOs) and plant extracts, have shown significant potential as effective green antimicrobial agents. However, they suffer from high volatility and low thermal stability resulting in their inefficient utilization in commercial settings. Among the various nanoencapsulation technologies reported, metal-organic frameworks (MOFs) have been recently investigated as potential nanocarriers of EOs in attempt to enhance their stability. Herein, we report the utilization of Zn-ascorbate MOF for the encapsulation of marjoram essential oil (MEO) with synergistic antioxidant and antibacterial activities. The prepared composite was thoroughly characterized a number of techniques and its antibacterial performance was investigated against various strains of Gram-negative and Gram-positive bacteria. The results demonstrated that the antioxidant activity originated from the ascorbic acid ligand (l-Asc), while the antibacterial activity originated from Zn ions as well as encapsulated MEO.
抗菌耐药性（AMR）已成为对公共卫生的巨大威胁，这导致迫切需要开发新技术来应对这一挑战。植物源药物，特别是精油（EOs）和植物提取物，已显示出作为有效的绿色抗菌剂的巨大潜力。然而，它们具有高挥发性和低热稳定性，导致其在商业环境中的利用效率低下。在报道的各种纳米封装技术中，金属有机框架（MOFs）最近被研究作为精油的潜在纳米载体，试图提高其稳定性。在此，我们报道了利用抗坏血酸锌MOF封装马郁兰精油（MEO），具有协同抗氧化和抗菌活性。通过多种技术对制备的复合材料进行了全面表征，并研究了其对各种革兰氏阴性菌和革兰氏阳性菌菌株的抗菌性能。结果表明，抗氧化活性源于抗坏血酸配体（l-Asc），而抗菌活性源于锌离子以及封装的MEO。
