Tajnšek Tia K, Svensson Grape Erik, Willhammar Tom, Antonić Jelić Tatjana, Javornik Uroš, Dražić Goran, Zabukovec Logar Nataša, Mazaj Matjaž
National Institute of Chemistry, Hajdrihova 19, 1000, Ljubljana, Slovenia.
Faculty of Inorganic Chemistry and Technology, University of Ljubljana, Večna pot 113, 1000, Ljubljana, Slovenia.
Commun Chem. 2022 Feb 25;5(1):24. doi: 10.1038/s42004-022-00639-x.
Bioapplication is an emerging field of metal-organic frameworks (MOF) utilization, but biocompatible MOFs with permanent porosity are still a rarity in the field. In addition, biocompatibility of MOF constituents is often overlooked when designing bioMOF systems, intended for drug delivery. Herein, we present the a Zn(II) bioMOF based on vitamin C as an independent ligand (bioNICS-1) forming a three-dimensional chiral framework with permanent microporosity. Comprehensive study of structure stability in biorelavant media in static and dynamic conditions demonstrates relatively high structure resistivity, retaining a high degree of its parent specific surface area. Robustness of the 3D framework enables a slow degradation process, resulting in controllable release of bioactive components, as confirmed by kinetic studies. BioNICS-1 can thus be considered as a suitable candidate for the design of a small drug molecule delivery system, which was demonstrated by successful loading and release of urea-a model drug for topical application-within and from the MOF pores.
生物应用是金属有机框架（MOF）利用的一个新兴领域，但具有永久孔隙率的生物相容性MOF在该领域仍然很少见。此外，在设计用于药物递送的生物MOF系统时，MOF成分的生物相容性常常被忽视。在此，我们展示了一种基于维生素C作为独立配体的锌（II）生物MOF（bioNICS-1），它形成了具有永久微孔率的三维手性框架。在静态和动态条件下对生物相关介质中结构稳定性的综合研究表明，其结构具有较高的抗性，保留了其母体比表面积的高度。三维框架的坚固性使得降解过程缓慢，导致生物活性成分可控释放，动力学研究证实了这一点。因此，BioNICS-1可被视为设计小型药物分子递送系统的合适候选物，这通过在MOF孔内成功加载和释放尿素（一种局部应用的模型药物）以及从MOF孔中释放得到了证明。
