He Lan, Cai Yundan, Feng Yuhong, Feng Tienan, Cademartiri Filippo, Shen E
Department of Ultrasound Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Ultrasound Medicine, Shanghai Sixth People's Hospital, Shanghai, China.
Cardiovasc Diagn Ther. 2024 Aug 31;14(4):668-678. doi: 10.21037/cdt-24-134. Epub 2024 Aug 16.
Wall shear stress (WSS) is related to the pathogenesis of atherosclerosis. WSS is affected by a variety of hemodynamic factors, and there is still a lack of accurate and objective methods for measuring it. This study sought to evaluate hemodynamic changes in WSS, WSS, WSS in the common carotid artery of healthy adults of different ages using vascular vector flow mapping (VFM).
A retrospective analysis was conducted on 70 healthy volunteers aged 20-89 years who were recruited from our Ultrasound Department between February 2021 and June 2021. An ultrasound system with a 3-15 MHz probe was used to determine regions of interest (ROIs) of the common carotid artery. VFM-based WSS measurements were obtained by selecting ROIs with optimal image quality from three full cardiac cycles. The participants were divided into the following seven age groups: the 20s group, the 30s group, the 40s group, the 50s group, the 60s group, the 70s group, and the 80s group. The WSS parameters were compared among the age groups. An analysis of variance or a Kruskal-Wallis test was used to evaluate the difference among the groups, and a Pearson analysis and linear regression were used for the correlation and trend analysis.
The WSS parameters were quantified using vascular VFM software. The WSS, WSS, WSS differed among the age groups and gradually decreased with age, the elderly were significantly lower than the young. The Pearson correlation coefficient of the WSS and age was -0.556 (P<0.001), that of the WSS and age was -0.461 (P<0.001), and that of the WSS and age was -0.308 (P<0.001). The WSS parameters with age are negatively correlated the carotid intima-media thickness differed between the groups.
The carotid WSS, WSS, WSS can be quantitatively and visually analyzed using the vascular VFM technique. In healthy adults of different ages, the carotid WSS, WSS, WSS decreased with age. Our findings about the normal values of carotid WSS maybe have clinical reference value for future studies.
壁面切应力（WSS）与动脉粥样硬化的发病机制有关。WSS受多种血流动力学因素影响，目前仍缺乏准确、客观的测量方法。本研究旨在利用血管矢量血流图（VFM）评估不同年龄健康成年人颈总动脉中WSS、WSS、WSS的血流动力学变化。
对2021年2月至2021年6月从我院超声科招募的70名年龄在20 - 89岁的健康志愿者进行回顾性分析。使用配备3 - 15 MHz探头的超声系统确定颈总动脉感兴趣区域（ROI）。通过从三个完整心动周期中选择图像质量最佳的ROI来获得基于VFM的WSS测量值。参与者被分为以下七个年龄组：20多岁组、30多岁组、40多岁组、50多岁组、60多岁组、70多岁组和80多岁组。比较各年龄组之间的WSS参数。采用方差分析或Kruskal - Wallis检验评估组间差异，采用Pearson分析和线性回归进行相关性和趋势分析。
使用血管VFM软件对WSS参数进行量化。各年龄组之间的WSS、WSS、WSS存在差异，且随年龄逐渐降低，老年人明显低于年轻人。WSS与年龄的Pearson相关系数为 - 0.556（P<0.001），WSS与年龄的Pearson相关系数为 - 0.461（P<0.001），WSS与年龄的Pearson相关系数为 - 0.308（P<0.001）。WSS参数与年龄呈负相关，各组间颈动脉内膜中层厚度存在差异。
可利用血管VFM技术对颈动脉WSS、WSS、WSS进行定量和可视化分析。在不同年龄的健康成年人中，颈动脉WSS、WSS、WSS随年龄降低。我们关于颈动脉WSS正常值的研究结果可能对未来研究具有临床参考价值。
