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新冠疫情时代头颈部坏死性筋膜炎:单机构经验

Necrotizing fasciitis of the head and neck in era of COVID-19: a single-institution experience.

作者信息

Zadjali Fahad Al, Hua Nadia, Tohmé Angelina, Alsaffar Hussain, Johnson-Obaseki Stephanie

机构信息

Al Nahdha Hospital, Head and Neck Oncology and Microvascular Reconstruction Surgery, Muscat, Oman.

The Ottawa Hospital, Department of Otolaryngology-Head and Neck Surgery, Ottawa, Canada.

出版信息

IJID Reg. 2024 Jul 30;12:100413. doi: 10.1016/j.ijregi.2024.100413. eCollection 2024 Sep.

DOI:10.1016/j.ijregi.2024.100413
PMID:39263679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11388291/
Abstract

OBJECTIVES

Necrotizing fasciitis (NF) of the head and neck is a critical condition, known for its severe impact and high mortality rates, often linked with diabetes, odontogenic infections, and immunosuppression. Observations from the University of Ottawa's Department of Otolaryngology - Head and Neck Surgery indicate an increase in NF cases since the COVID-19 pandemic began, suggesting a possible association between COVID-19 and NF. This study aims to assess the incidence of NF since the pandemic's onset and explore its association with COVID-19.

DESIGN

Conducted as a single-center retrospective review from January 1, 2015 to April 7, 2023, this study included patients aged over 18 years with histopathologic confirmation of NF, analyzing clinical risk factors, treatment, and outcomes. Patients were divided into pre- and post-COVID-19 groups for comparison.

RESULTS

Of 16 patients, 68.7% were in the post-COVID-19 group, with a notable increase in 2022. The most common risk factors were diabetes mellitus (43.8%) and history of odontogenic infection or extraction (31.3%). Only one patient (6.3%) presented with concomitant COVID-19 infection and NF. All patients underwent treatment with serial surgical debridement and intravenous antibiotics with mortality rates rising to 12.5% after the pandemic.

CONCLUSIONS

Our study demonstrates an increased incidence of NF cases in our institution after the COVID-19 pandemic.

摘要

目的

头颈部坏死性筋膜炎(NF)是一种危急病症,以其严重影响和高死亡率而闻名,常与糖尿病、牙源性感染和免疫抑制相关。渥太华大学耳鼻咽喉 - 头颈外科的观察表明,自新冠疫情开始以来,NF病例有所增加,这表明新冠病毒与NF之间可能存在关联。本研究旨在评估疫情爆发以来NF的发病率,并探讨其与新冠病毒的关联。

设计

本研究为单中心回顾性研究,时间跨度从2015年1月1日至2023年4月7日,纳入年龄超过18岁且经组织病理学确诊为NF的患者,分析临床危险因素、治疗方法及治疗结果。将患者分为新冠疫情前和后两组进行比较。

结果

16例患者中,68.7%属于新冠疫情后组,2022年有显著增加。最常见的危险因素是糖尿病(43.8%)和牙源性感染或拔牙史(31.3%)。仅有1例患者(6.3%)同时感染新冠病毒和NF。所有患者均接受了系列手术清创和静脉注射抗生素治疗,疫情后死亡率升至12.5%。

结论

我们的研究表明,新冠疫情后我们机构内NF病例的发病率有所增加。