和 基因多态性与中国人群的髋骨关节炎相关。
Genetic polymorphisms of and are associated with hip osteoarthritis in the Chinese population.
机构信息
Department of Orthopedics Surgery, Third People's Hospital of Jiujiang City, Jiangxi Province, China.
出版信息
Biomark Med. 2024 Aug 17;18(15-16):695-702. doi: 10.1080/17520363.2024.2389030. Epub 2024 Sep 12.
Abstract
A large genome-wide analyses of UK Biobank data reported 15 novel associated with the susceptibility of hip osteoarthritis (HOA). We aimed to replicate the association of these with HOA in the Chinese population. A total of 13 Single Nucleotide Polymorphisms were genotyped in 892 HOA patients and 1123 healthy controls. The risk allele frequency of rs62578127 and rs11059094 was significantly higher in the patients than in the controls. The mRNA expression of ( = 0.01) and ( = 0.001) were significantly increased in HOA tissues. We successfully replicated two novel susceptible of HOA and further characterized two potential causative genes.
摘要
一项针对英国生物库数据的大型全基因组分析报告了 15 个与髋骨关节炎（HOA）易感性相关的新。我们旨在复制这些与中国人群 HOA 关联的。在 892 名 HOA 患者和 1123 名健康对照中，共检测了 13 个单核苷酸多态性。rs62578127 和 rs11059094 的风险等位基因频率在患者中明显高于对照组。（=0.01）和（=0.001）在 HOA 组织中的表达显著增加。我们成功地复制了两个新的 HOA 易感，并进一步鉴定了两个潜在的致病基因。
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