特发性炎性肌病成年患者的自我报告身体活动与疲劳及其与焦虑和抑郁的关联：MIHRA心理影响与MIHRA运动及康复科学工作组合作
Self-reported physical activity and fatigue and its associations to anxiety and depression in adult patients with idiopathic inflammatory myopathies:a MIHRA psychological impact and MIHRA exercise and rehabilitation scientific working groups collaboration.
作者信息
Andreasson Kristofer M, Espinosa-Ortega Fabricio, Sandlund Heléne, Alexanderson Helene
机构信息
Karolinska Institutet, Department of Medicine Solna, Division of Rheumatology, Stockholm; and Women's Health and Health Professionals Theme, Medical Unit Health Professionals, Karolinska University Hospital, Stockholm, Sweden.
Karolinska Institutet, Department of Medicine Solna, Division of Rheumatology, Stockholm, and Karolinska University Hospital, Department of Gastroenterology, Dermatology and Rheumatology, Medical Unit Inflammation and Aging, Stockholm, Sweden.
出版信息
Clin Exp Rheumatol. 2025 Feb;43(2):230-240. doi: 10.55563/clinexprheumatol/5u5ah3. Epub 2024 Sep 10.
OBJECTIVES
To evaluate self-reported physical activity (PA) levels as well as the relationship between PA, anxiety, depression, quality of life, pain, fatigue, disease activity, and organ damage in patients with idiopathic inflammatory myopathies (IIM).
METHODS
All adult patients registered at the rheumatology clinic at Karolinska University Hospital in Stockholm, Sweden (2019-2022) were eligible to participate. Questionnaires measuring anxiety, depression (HADS), and PA (IPAQ) were provided during yearly check-up or by mail, due to reduced in-person visits amid the Covid-19 pandemic. Additional data was obtained from the Swedish Rheumatology Quality Registry.
RESULTS
Of 488 invited patients, 336 agreed to participate, and 246 completed the questionnaires. Median (range) age was 64 (20-88) years, median disease duration five (0.3-61) years and two-thirds were women. Notably, 82% reported moderate/high level of PA. Probable anxiety and depression were experienced by 25% and 14%, respectively. The findings indicated a potential protective effect of PA against depression (OR 0.23, CI 0.06-0.95). Conversely, patients who were physically inactive had poorer mental health, reduced muscle function, increased organ damage, and fatigue. Fatigue demonstrated a progressive link to heightened risks of anxiety (2%, 2-4%) or depression (3%, 1-6%).
CONCLUSIONS
Most patients with IIM reported being physically active. The study highlights the potential influence of PA on mental health and its role in mitigating risks associated with depression and fatigue among IIM-patients. It also underscores the importance of patient-reported outcomes, and their role in understanding and improving healthcare interventions. Further research is needed to uncover causes and confirm these associations.
目的
评估特发性炎症性肌病（IIM）患者自我报告的身体活动（PA）水平，以及PA、焦虑、抑郁、生活质量、疼痛、疲劳、疾病活动和器官损伤之间的关系。
方法
瑞典斯德哥尔摩卡罗林斯卡大学医院风湿病诊所登记的所有成年患者（2019 - 2022年）均有资格参与。由于在新冠疫情期间面对面就诊减少，在年度检查期间或通过邮件提供了测量焦虑、抑郁（医院焦虑抑郁量表，HADS）和PA（国际体力活动问卷，IPAQ）的问卷。从瑞典风湿病质量登记处获得了其他数据。
结果
在488名受邀患者中，336名同意参与，246名完成了问卷。中位（范围）年龄为64（20 - 88）岁，中位病程为5（0.3 - 61）年，三分之二为女性。值得注意的是，82%的患者报告PA水平为中度/高度。分别有25%和14%的患者存在可能的焦虑和抑郁。研究结果表明PA对抑郁有潜在的保护作用（比值比0.23，可信区间0.06 - 0.95）。相反，身体不活动的患者心理健康较差，肌肉功能下降，器官损伤增加，且疲劳感更强。疲劳与焦虑（2%，2 - 4%）或抑郁（3%，1 - 6%）风险增加呈渐进性关联。
结论
大多数IIM患者报告身体活动。该研究强调了PA对心理健康的潜在影响及其在减轻IIM患者抑郁和疲劳相关风险中的作用。它还强调了患者报告结局的重要性及其在理解和改善医疗保健干预措施中的作用。需要进一步研究以揭示原因并证实这些关联。
Zotero 插件