COVID-19 第三剂疫苗接种对肾移植受者抗原特异性 T 细胞数量的影响。
The Impact of COVID-19 Third Dose Vaccination on the Magnitude of Antigen Specific T Cells in Kidney Transplant Patients.
机构信息
Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
出版信息
Physiol Res. 2024 Aug 31;73(4):655-664. doi: 10.33549/physiolres.935318.
Measuring T cell response can add information about antivirus immunity provided by antibody test results. The study evaluates the impact of a third mRNA COVID-19 vaccine dose on T cell response and antibody production in kidney transplant recipients (25 KTRs) versus healthy controls (26 Hc). Results show a significant rise in S-activated CD4+CD154+IFN?+TNF?+ double producer cells in both KTRs (p=0.025) and Hc (p=0.009) as well as increased spike antibody response in KTRs (p=0.00019) and Hc (p=3.10-8) third-month post-third dose. Moreover, the study revealed a drop in seronegative KTRs (non-responders) from 9/25 (36%) pre-third dose to 2/25 (7%) at 3 months post-third dose while 5/9 (56%) of non-responders post-second dose showed specific T cell responses. Notably, the third dose significantly improved seroconversion rates in both KTRs and Hc, although Hc individuals exhibited higher antibody levels. Key words: mRNA COVID-19 vaccine, T cells, SARS-CoV-2 antibodies, Kidney transplantation, mRNA vaccination.
测量 T 细胞反应可以为抗体检测结果提供的抗病毒免疫信息提供补充。本研究评估了第三剂 mRNA COVID-19 疫苗对肾移植受者（25 名 KTR）与健康对照（26 名 Hc）的 T 细胞反应和抗体产生的影响。结果显示，KTR 和 Hc 中的 S 激活的 CD4+CD154+IFN?+TNF?+双产细胞均显著增加（KTR：p=0.025；Hc：p=0.009），且 KTR 和 Hc 的 Spike 抗体反应均增强（KTR：p=0.00019；Hc：p=3.10-8），这是在第三剂后第三个月观察到的。此外，研究显示，在第三剂前，9/25（36%）名血清阴性的 KTR（无应答者）转为血清阴性，而在第三剂后 3 个月，这一比例降至 2/25（7%），而在第二剂后无应答者中，有 5/9（56%）表现出了特异性 T 细胞反应。值得注意的是，第三剂显著提高了 KTR 和 Hc 的血清转化率，尽管 Hc 个体的抗体水平更高。关键词：mRNA COVID-19 疫苗，T 细胞，SARS-CoV-2 抗体，肾移植，mRNA 疫苗接种。
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