OprF 孔蛋白作为恢复表达获得性碳青霉烯酶的碳青霉烯类药物敏感性的潜在靶标。
The OprF porin as a potential target for the restoration of carbapenem susceptibility in expressing acquired carbapenemases.
机构信息
European Institute for Emerging Antibiotic Resistance, Pasteur Institute, Lille, France.
European Institute for Emerging Antibiotic Resistance, University of Fribourg, Fribourg, Switzerland.
出版信息
Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0076124. doi: 10.1128/aac.00761-24. Epub 2024 Sep 12.
Abstract
Carbapenem resistance in is primarily due to the acquisition of carbapenemases and is often associated with a diminution of the membrane permeability. The outer membrane protein, OprD, is a well-known route, by which carbapenems, predominantly imipenem, can enter the cell, and its loss has been associated with reduced susceptibility to imipenem. In this study, we investigated the antibiotic susceptibility patterns of isogenic mutants containing various acquired β-lactamases, including carbapenemases, in a porin-depleted background. We identified that the deletion of was associated with some recovery of susceptibility to carbapenems.
摘要
碳青霉烯类耐药在 中主要是由于获得碳青霉烯酶所致，通常与膜通透性降低有关。外膜蛋白 OprD 是碳青霉烯类药物（主要是亚胺培南）进入细胞的已知途径，其缺失与对亚胺培南的敏感性降低有关。在本研究中，我们在孔蛋白缺失的背景下，研究了含有各种获得性β-内酰胺酶（包括碳青霉烯酶）的同源 突变体的抗生素敏感性模式。我们发现 的缺失与对碳青霉烯类药物的敏感性恢复有关。
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