Research Institute for Environment and Health, Nanjing University of Information Science and Technology, Nanjing 210044, China.
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Food Funct. 2024 Sep 30;15(19):9707-9717. doi: 10.1039/d4fo03077j.
: The aim of the present study was to conduct a meta-analysis of observational studies to explore the latest evidence on the influence of whole grain and fiber consumption on total chronic liver diseases. : We searched the PubMed and Web of Science online databases and reference lists of eligible articles up to June, 2024. : The odds ratio (OR) between whole grain intake and total chronic liver disease risk was 0.90 (95% confidence interval (CI): 0.81 to 0.99, < 0.001) and indicated an OR of 0.65 (95% CI: 0.57 to 0.74, < 0.001) between fiber intake and total chronic liver disease risk when comparing the highest and lowest total intake, both indicating a significant negative correlation. Furthermore, subgroup analysis revealed that the protective effect of whole grains on chronic liver diseases was the most significant in cirrhosis (OR = 0.65; 95% CI: 0.57 to 0.74) and mortality (OR = 0.37; 95% CI: 0.29 to 0.47). : Whole grain and fiber intake has a protective effect on the risk of chronic liver diseases.
: 本研究旨在对观察性研究进行荟萃分析，以探讨全谷物和纤维摄入对慢性肝脏疾病的影响的最新证据。 : 我们检索了 PubMed 和 Web of Science 在线数据库以及合格文章的参考文献列表，检索截至 2024 年 6 月。 : 全谷物摄入量与慢性肝脏疾病总风险之间的比值比（OR）为 0.90（95%置信区间（CI）：0.81 至 0.99，<0.001），表明纤维摄入量与慢性肝脏疾病总风险之间的 OR 为 0.65（95%CI：0.57 至 0.74，<0.001），当比较最高和最低总摄入量时，这都表明存在显著的负相关关系。此外，亚组分析表明，全谷物对肝硬化（OR=0.65；95%CI：0.57 至 0.74）和死亡率（OR=0.37；95%CI：0.29 至 0.47）的慢性肝脏疾病的保护作用最为显著。 : 全谷物和纤维摄入对慢性肝脏疾病的风险具有保护作用。
