Fotros Danial, Hekmatdoost Azita, Pashayee-Khamene Fereshteh, Karimi Sara, Ahmadzadeh Saleheh, Saberifiroozi Mehdi, Hatami Behzad, Yari Zahra
Clinical Nutrition and dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Nutr J. 2025 Jan 25;24(1):15. doi: 10.1186/s12937-025-01086-9.
Cirrhosis is a medical condition marked by persistent liver damage, which leads to the development of fibrous tissue and compromised liver function. In the present study, we decided to investigate the possibility of a connection between the consumption of fermentable olig-, di-, monosaccharides, and polyols (FODMAPs) and mortality rates in cirrhotic patients by utilizing data obtained from a prospective cohort study.
This cohort study enrolled 166 ambulatory patients from two hospitals in Tehran, Iran, between 2016 and 2018, and followed them up for 5 48 months until April 30, 2022. During the 3,955 person-months of follow-up, 43 fatalities were recorded (36 men and 7 women). The study classified participants into three groups based on their FODMAPs consumption and assessed the risk of mortality using Cox proportional hazards regression models.
Total FODMAPs intake was associated with increased overall mortality risk (T3 vs. T1, HR = 3.5; 95%CI: 1.05, 11.7; P-trend = 0.036). This significant trend was also observed for total fructans (T3 vs. T1, HR = 5.15; 95% CI: 1.15, 23.2; P-trend = 0.006) and fructose (T3 vs. T1, HR = 5.55; 95% CI: 0.54, 57.14; P-trend = 0.018). Mortality risk was U-shaped with galactooligosaccharide intake, a lower mortality risk was observed with lactose intake and a higher mortality risk with polyols intake, although these associations did not reach statistical significance.
In conclusion, this study highlights a higher risk of mortality with higher intake of fructans, excess fructose and total FODMAPs.
肝硬化是一种以持续性肝损伤为特征的病症，会导致纤维组织形成和肝功能受损。在本研究中，我们决定利用一项前瞻性队列研究获得的数据，调查可发酵寡糖、双糖、单糖和多元醇（FODMAPs）的摄入量与肝硬化患者死亡率之间存在关联的可能性。
这项队列研究在2016年至2018年间招募了来自伊朗德黑兰两家医院的166名门诊患者，并对他们进行了48个月的随访，直至2022年4月30日。在3955人月的随访期间，记录了43例死亡病例（36名男性和7名女性）。该研究根据参与者的FODMAPs摄入量将其分为三组，并使用Cox比例风险回归模型评估死亡风险。
FODMAPs的总摄入量与总体死亡风险增加相关（T3组与T1组相比，HR = 3.5；95%CI：1.05，11.7；P趋势 = 0.036）。在总果聚糖（T3组与T1组相比，HR = 5.15；95%CI：1.15，23.2；P趋势 = 0.006）和果糖（T3组与T1组相比，HR = 5.55；95%CI：0.54，57.14；P趋势 = 0.018）方面也观察到了这一显著趋势。低聚半乳糖摄入量与死亡风险呈U形关系，乳糖摄入量与较低的死亡风险相关，多元醇摄入量与较高的死亡风险相关，尽管这些关联未达到统计学显著性。
总之，本研究强调了果聚糖、过量果糖和FODMAPs总摄入量较高时死亡风险更高。
