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光诱导HCl介导的喹啉与醇和醚的交叉脱氢偶联反应

Photoinduced HCl-Mediated Cross-Dehydrogenative Coupling of Quinolines with Alcohols and Ethers.

作者信息

Guo Feixiang, Guo Yingchang, Sun Qianqian, Zhang Tao, Wang Yakun, Fang Lizhen

机构信息

School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan 453003, China.

The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453003, China.

出版信息

J Org Chem. 2024 Oct 4;89(19):14204-14208. doi: 10.1021/acs.joc.4c01620. Epub 2024 Sep 12.

Abstract

Via light irradiation, cross-dehydrogenative coupling of quinolines with alcohols and ethers was achieved under mild conditions. A stoichiometric amount of HCl and room temperature were necessary to promote the reaction. A green Minisci-type cross-dehydrogenative coupling reaction was performed without an oxidant or a transition-metal catalyst.

摘要

通过光照射,喹啉与醇和醚的交叉脱氢偶联在温和条件下得以实现。促进该反应需要化学计量的HCl和室温。在没有氧化剂或过渡金属催化剂的情况下进行了绿色的Minisci型交叉脱氢偶联反应。

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