Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, Arizona.
Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, Arizona.
J Surg Res. 2024 Oct;302:891-896. doi: 10.1016/j.jss.2024.07.095. Epub 2024 Sep 11.
The measure of mortality following a major complication (failure to rescue [FTR]) provides a quantifiable assessment of the level of care provided by trauma centers. However, there is a lack of data on the effects of patient-related factors on FTR incidence. The aim of this study was to identify the role of frailty on FTR incidence among geriatric trauma patients with ground-level falls (GLFs).
This is a retrospective analysis of the American College of Surgeons Trauma Quality Improvement Program database (2017-2020). All geriatric (aged ≥ 65 ys) trauma patients with GLFs admitted to a level I trauma center were included. Transferred patients, those with severe head injuries (head abbreviated injury scale ≥ 3), and those who died within 24 h of admission or whose length of stay was ≤1 d were excluded. FTR was defined as death following a major complication (cardiac arrest, myocardial infarction, sepsis, acute respiratory distress syndrome, unplanned intubation, acute renal failure, cerebrovascular accident, ventilator-associated pneumonia, or pulmonary embolism). Patients were stratified into frail (F) and nonfrail (NF) based on the 11-Factor Modified Frailty Index. Multivariable regression analyses were performed to identify the independent effect of frailty on the incidence of FTR.
Over 4 ys, 34,100 geriatric patients with GLFs were identified, of whom 9140 (26.8%) were F. The mean (standard deviation) age was 78 (7) years and 65% were female. The median injury severity score was 9 (5-10) with no difference among F and NF groups (P = 0.266). Overall, F patients were more likely to develop major complications (F: 3.6% versus NF: 2%, P < 0.001) and experience FTR (F: 1.8%% versus NF: 0.6%, P < 0.001). Moreover, among patients with major complications, F patients were more likely to die (F: 47% versus NF: 27%, P < 0.001). On multivariable regression analysis, frailty was identified as an independent predictor of major complications (adjusted odds ratio: 1.98, 95% confidence interval [1.70-2.29], P < 0.001) and FTR (adjusted odds ratio: 2.26, 95% confidence interval [1.68-3.05], P < 0.001).
Among geriatric trauma patients with GLFs, frailty increases the risk-adjusted odds of FTR by more than two times. One in every two F patients with a major complication does not survive to discharge. Future efforts should concentrate on improving patient-related and hospital-related factors to decrease the risk of FTR among these vulnerable populations.
主要并发症(抢救失败[FTR])后的死亡率衡量了创伤中心提供的护理水平。然而,关于患者相关因素对 FTR 发生率的影响的数据还很缺乏。本研究的目的是确定脆弱性在老年创伤患者地面水平跌倒(GLF)后 FTR 发生率中的作用。
这是美国外科医师学院创伤质量改进计划数据库(2017-2020 年)的回顾性分析。所有年龄≥65 岁的 GLF 入院一级创伤中心的老年创伤患者均被纳入研究。排除了转院患者、严重头部损伤(头部简明损伤量表≥3)患者和入院 24 小时内死亡或住院时间≤1 天的患者。FTR 定义为主要并发症(心搏骤停、心肌梗死、脓毒症、急性呼吸窘迫综合征、计划性插管、急性肾衰竭、脑血管意外、呼吸机相关性肺炎或肺栓塞)后死亡。根据 11 因素改良脆弱性指数,将患者分为脆弱(F)和非脆弱(NF)。采用多变量回归分析确定脆弱性对 FTR 发生率的独立影响。
在 4 年多的时间里,共确定了 34100 例 GLF 的老年患者,其中 9140 例(26.8%)为 F。平均(标准差)年龄为 78(7)岁,65%为女性。损伤严重程度中位数为 9(5-10),F 和 NF 组之间无差异(P=0.266)。总体而言,F 患者更有可能发生主要并发症(F:3.6%比 NF:2%,P<0.001)和经历 FTR(F:1.8%比 NF:0.6%,P<0.001)。此外,在发生主要并发症的患者中,F 患者更有可能死亡(F:47%比 NF:27%,P<0.001)。多变量回归分析显示,脆弱性是主要并发症(调整优势比:1.98,95%置信区间[1.70-2.29],P<0.001)和 FTR(调整优势比:2.26,95%置信区间[1.68-3.05],P<0.001)的独立预测因子。
在 GLF 的老年创伤患者中,脆弱性使 FTR 的风险调整后几率增加了两倍以上。每两个发生主要并发症的 F 患者中,就有一个不能存活至出院。未来的努力应集中于改善与患者相关和与医院相关的因素,以降低这些脆弱人群发生 FTR 的风险。