宿主与肠道微生物群之间的对话揭示了一种化疗的“银弹”治疗选择。
Conversation between host and gut microbiota unveils a "silver bullet" therapeutic option for chemotherapy.
机构信息
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China; Xiang'an Hospital of Xiamen University, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.
出版信息
Cell Host Microbe. 2024 Sep 11;32(9):1455-1457. doi: 10.1016/j.chom.2024.08.008.
Chemotherapy is associated with the induction of intestinal microbiota dysbiosis and gastrointestinal injuries. In this Cell Host & Microbe issue, Anderson et al. demonstrate that chemotherapy-induced epithelial cell apoptosis drives microbiota imbalance and transcriptional rewiring, which in turn delays intestinal recovery.
化疗会引起肠道微生物群落失调和胃肠道损伤。在本期《细胞宿主与微生物》中，Anderson 等人证明，化疗引起的上皮细胞凋亡会导致微生物群落失衡和转录重排，进而延缓肠道恢复。
Zotero 插件