胰腺疾病中的肠道微生物组。
The Gut Microbiome in Pancreatic Disease.
机构信息
Division of Gastroenterology, Department of Medicine, Johns Hopkins Medical Institution, Baltimore, Maryland.
Department of Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India; Wellcome DBT Laboratories, Asian Healthcare Foundation, Hyderabad, India.
出版信息
Clin Gastroenterol Hepatol. 2019 Jan;17(2):290-295. doi: 10.1016/j.cgh.2018.08.045. Epub 2018 Aug 23.
Abstract
The gut microbiome increasingly is recognized for its role in human health and disease. Initial evidence has indicated that gut microbial dysbiosis is associated with several pancreatic diseases. Although it is not known if these associations are causative, gut dysbiosis is hypothesized to mediate chronic proinflammatory changes in the pancreas. Further mechanistic and epidemiologic studies of the microbiome are needed. Ultimately, targeted modulation of the microbiota could have therapeutic value.
摘要
肠道微生物组越来越被认为在人类健康和疾病中发挥作用。初步证据表明，肠道微生物失调与几种胰腺疾病有关。尽管尚不清楚这些关联是否具有因果关系，但据推测，肠道失调可介导胰腺的慢性炎症性变化。需要进一步进行微生物组的机制和流行病学研究。最终，靶向调节微生物群可能具有治疗价值。
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