Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology CePT, Medical University of Warsaw, Warszawa, Poland.
Department of Organic Chemistry, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.
Planta Med. 2024 Oct;90(13):976-991. doi: 10.1055/a-2401-6049. Epub 2024 Sep 12.
Traditional medicine has long recognized the therapeutic potential of , and recent scientific research has shed light on the pharmacological properties of this plant. The bioactive compounds that can be extracted from it, such as the sesquiterpene lactones arctigenin, arctiin, and cnicin, are very interesting to researchers.In this article, based on available data from pre-clinical and studies, we delve into the pharmacology of the active constituents of this plant to explore its potential therapeutic applications and underlying mechanisms of action. In addition, we present a computer analysis designed to reveal the pharmacokinetic and toxicological properties of the main phytochemicals that are active in through new techniques and predictive tools such as SwissADME and PubChem.The data from the study presented here support the traditional use of , as well as its promise as a source of new therapeutic chemical compounds.
传统医学早就认识到 的治疗潜力，最近的科学研究也揭示了这种植物的药理学特性。可以从中提取的生物活性化合物，如倍半萜内酯类化合物土木香内酯、土木香苦素和川陈皮素，引起了研究人员的极大兴趣。在本文中，我们根据临床前和临床研究的现有数据，深入研究了这种植物的活性成分的药理学，以探索其潜在的治疗应用和作用机制。此外，我们还展示了一项计算机分析，旨在通过新的技术和预测工具，如 SwissADME 和 PubChem，揭示在 中具有活性的主要植物化学物质的药代动力学和毒理学特性。本文所呈现的临床前研究数据支持 的传统用途，以及它作为新的治疗性化学化合物来源的潜力。
