Dycha Natalia, Michalak-Tomczyk Magdalena, Jachuła Jacek, Okoń Estera, Jarząb Agata, Tokarczyk Joanna, Koch Wojciech, Gaweł-Bęben Katarzyna, Kukula-Koch Wirginia, Wawruszak Anna
Department of Pharmacognosy with Medical Plants Garden, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland.
Department of Physiology and Toxicology, The John Paul II Catholic University of Lublin, 1I Konstantynów Str., 20-708 Lublin, Poland.
Cancers (Basel). 2025 May 11;17(10):1625. doi: 10.3390/cancers17101625.
Melanoma is one of the most aggressive forms of skin cancer, characterized by high metastatic potential and resistance to conventional therapies. Natural compounds, particularly terpenoids, have gained attention for their chemopreventive potential and anticancer properties. These plant-derived compounds exhibit diverse biological activities, e.g., cell viability and proliferation inhibition, apoptosis induction, cell cycle regulation, and immune system modulation. The review evaluates the current state of the art on the chemopreventive and anticancer activity of lupane- (betulinic acid), oleanane- (oleanolic acid, β-amyrin, escin, hederagenin, glycyrrhetinic acid), and ursane-type (ursolic acid, asiatic acid, madecassic acid, α-amyrin) triterpenoids in melanoma, highlighting their mechanisms of action, therapeutic potential, and challenges in clinical application.
黑色素瘤是最具侵袭性的皮肤癌形式之一，其特点是具有高转移潜能且对传统疗法耐药。天然化合物，特别是萜类化合物，因其化学预防潜力和抗癌特性而受到关注。这些植物来源的化合物具有多种生物学活性，例如细胞活力和增殖抑制、凋亡诱导、细胞周期调控以及免疫系统调节。本综述评估了羽扇豆烷型（桦木酸）、齐墩果烷型（齐墩果酸、β-香树脂醇、七叶皂苷、常春藤皂苷元、甘草次酸）和乌苏烷型（熊果酸、积雪草苷、羟基积雪草苷、α-香树脂醇）三萜类化合物在黑色素瘤化学预防和抗癌活性方面的研究现状，重点介绍了它们的作用机制、治疗潜力以及临床应用中的挑战。
