实施改变有氧运动和力量运动行为：一项随机、I 期研究的结果，该研究旨在确定一种在线运动方案在多发性硬化症患者中的安全性、可行性和消费者评估。
Implementing changing behaviour towards aerobic and strength exercise: Results of a randomised, phase I study determining the safety, feasibility, and consumer-evaluation of an online exercise program in persons with multiple sclerosis.
机构信息
School of Allied Health (Exercise Science), Murdoch University, Murdoch, WA, Australia.
School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.
出版信息
Contemp Clin Trials. 2024 Nov;146:107686. doi: 10.1016/j.cct.2024.107686. Epub 2024 Sep 11.
BACKGROUND
Many people with MS do not meet the recommended exercise regime to elicit health benefits. This study aimed to determine the feasibility, safety, acceptability, and appropriateness of an exercise intervention delivered online to persons with MS that meets current exercise recommendations and behaviour change principles.
METHODS
Seventy-two participants (age: 43.3 ± 13.3 years) with mild to moderate MS were stratified according to previous exercise behaviour and block-randomised into one of three groups: Control (CON; n = 24), General Exercise (GE; n = 24) who at screening did not meet current exercise recommendations, and Advanced Exercise, (AE; n = 24) who at screening met the current exercise recommendations. GE and AE groups received a four-month online-supervised, behaviour change theory-based exercise program and were assessed at baseline, four-months, five-months, and eleven-months for physical activity participation. The feasibility of process, resources, management, and scientific outcomes was assessed.
RESULTS
Of 198 potential participants, 143 met the eligibility criteria (72 %), and 72 were randomised. Fifty-three participants completed the intervention (74 % immediate retention), and 44 were retained at the six-month follow-up (61 %). Personnel time was 369 h, and total per-participant cost was Au$1036.20. Adherence rate to ≥70 % of exercise sessions was 73 % (GE) and 38 % (AE). The GE group observed a small magnitude of improvement in physical activity (d = -0.23).
CONCLUSIONS
An online exercise program embedded with behaviour interventions for either GE or AE appears feasible, acceptable, appropriate and safe and may show long-term efficacy in increased exercise behaviours for persons with mild to moderate MS.
TRIAL REGISTRATION
ANZCRT number ACTRN12619000228189p.
背景
许多多发性硬化症患者未能达到推荐的运动方案以获得健康益处。本研究旨在确定一种在线运动干预措施的可行性、安全性、可接受性和适当性，该措施针对的是符合当前运动建议和行为改变原则的多发性硬化症患者。
方法
72 名参与者（年龄：43.3±13.3 岁）根据先前的运动行为进行分层，并按块随机分为三组：对照组（CON；n=24）、一般运动组（GE；n=24），他们在筛查时不符合当前的运动建议，以及高级运动组（AE；n=24），他们在筛查时符合当前的运动建议。GE 和 AE 组接受为期四个月的在线监督、基于行为改变理论的运动计划，并在基线、四个月、五个月和十一个月时评估身体活动参与情况。评估了过程、资源、管理和科学结果的可行性。
结果
在 198 名潜在参与者中，有 143 名符合入选标准（72%），72 名被随机分配。53 名参与者完成了干预（74%的即时保留率），44 名在六个月随访时保留（61%）。人员时间为 369 小时，每位参与者的总费用为 1036.20 澳元。GE 组的运动课程参与率达到≥70%，为 73%，AE 组为 38%。GE 组的身体活动量略有改善（d=-0.23）。
结论
对于 GE 或 AE，嵌入行为干预的在线运动计划似乎是可行的、可接受的、适当的和安全的，并且可能在增加轻度至中度多发性硬化症患者的运动行为方面显示出长期疗效。
试验注册
ANZCRT 编号 ACTRN12619000228189p。
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