Learmonth Yvonne C, Adamson Brynn C, Kinnett-Hopkins Dominique, Bohri Maria, Motl Robert W
School of Psychology and Exercise Science, Murdoch University, Murdoch, WA, 6150, Australia.
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Contemp Clin Trials. 2017 Mar;54:84-97. doi: 10.1016/j.cct.2016.11.012. Epub 2016 Dec 2.
There is increasing recognition that exercise is an efficacious strategy for managing many consequences of multiple sclerosis (MS), yet persons with MS are not engaging in sufficient exercise for accruing health benefits. Poor exercise uptake might be associated with the design of previous research. We conducted a randomised controlled trial (RCT) for examining the feasibility of a 4-month home-based, exercise-training program designed based on recent physical activity guidelines for MS and supplemented by behavioural strategies for compliance. Feasibility was assessed in the domains of process (e.g., recruitment), resource (e.g., monetary costs), management (e.g., personnel time requirements) and scientific outcomes (e.g., treatment effect). We recruited persons with mild-to-moderate MS who were randomised into an intervention or wait-list control condition. Intervention participants received a pedometer, elastic resistance bands, DVD, training manual, calendars, log-book, video coaching calls and newsletters. Participants in both conditions completed home-based assessments before and after the 4-month period. Ninety-nine persons with MS were assessed for eligibility, and 57 were randomised. Fifty-one persons completed the study (90%). Total costs of the study were US $5331.03. Personnel time to conduct the study totaled 263h. Participants in the intervention group complied fully with 71% of all exercise sessions. There was a moderate increase in self-reported exercise behaviour of the intervention participants as measured by the Godin Leisure-Time Exercise Questionnaire (d≥0.5). The results support the feasibility and acceptability of a home-based exercise intervention based on physical activity guidelines and supplemented with behavioural strategies for adults with mild-to-moderate MS.
人们越来越认识到，运动是管理多发性硬化症（MS）多种后果的有效策略，但MS患者并未进行足够的运动以获得健康益处。运动参与率低可能与先前研究的设计有关。我们进行了一项随机对照试验（RCT），以检验一项为期4个月的居家运动训练计划的可行性，该计划基于MS最新身体活动指南设计，并辅以行为策略以确保依从性。在过程（如招募）、资源（如金钱成本）、管理（如人员时间要求）和科学结果（如治疗效果）等领域评估了可行性。我们招募了轻度至中度MS患者，将其随机分为干预组或等待名单对照组。干预组参与者收到一个计步器、弹力带、DVD、训练手册、日历、日志、视频辅导电话和时事通讯。两组参与者在4个月期间前后均完成了居家评估。对99名MS患者进行了资格评估，57名被随机分组。51人完成了研究（90%）。研究总费用为5331.03美元。开展该研究的人员总时间为263小时。干预组参与者完全遵守了所有运动课程的71%。根据戈丁休闲时间运动问卷测量，干预组参与者自我报告的运动行为有适度增加（d≥0.5）。结果支持了一项基于身体活动指南并辅以行为策略的居家运动干预对轻度至中度MS成年人的可行性和可接受性。
