Department of Psychology, UiT the Arctic University of Norway, Tromsø, Norway.
Department of Psychology, UiT the Arctic University of Norway, Tromsø, Norway.
Appetite. 2024 Dec 1;203:107671. doi: 10.1016/j.appet.2024.107671. Epub 2024 Sep 10.
Low-protein diets affect body weight, body composition, food intake, and food preferences in mice. Furthermore, single periods of protein restriction can have lasting effects on these parameters. We sought to examine the effect of multiple, short, bouts of protein restriction, relative to long-term maintenance on either a control (NR) or protein-restricted (PR) diet. We found that male mice experiencing intermittent protein restriction (IPR) were indistinguishable from NR mice in terms of body weight and composition, but had food intake and plasma ghrelin as high as mice on PR diet, even when they were returned to control diet. This was not found in female mice. The results of this experiment highlight the importance of diet history on food intake and ghrelin levels in male mice, and the difference in how PR diet might affect male and female mice.
低蛋白饮食会影响小鼠的体重、身体成分、食物摄入量和食物偏好。此外，单次的蛋白质限制期会对这些参数产生持久的影响。我们试图研究多次短期蛋白质限制期（IPR）与长期维持在对照（NR）或蛋白质限制（PR）饮食相比，对这些参数的影响。我们发现，经历间歇性蛋白质限制（IPR）的雄性小鼠在体重和身体成分方面与 NR 小鼠没有区别，但食物摄入量和血浆生长激素释放肽（ghrelin）水平与 PR 饮食的小鼠一样高，即使它们被重新喂食对照饮食也是如此。而雌性小鼠则没有出现这种情况。这个实验的结果强调了饮食史对雄性小鼠食物摄入量和生长激素释放肽（ghrelin）水平的重要性，以及 PR 饮食可能对雄性和雌性小鼠产生不同影响的差异。
