Isikay Ahmet Ilkay, Gurses Muhammet Enes, Gecici Neslihan Nisa, Baylarov Baylar, Cekic Efecan, Narin Firat, Karakaya Dicle, Hanalioglu Sahin, Bilginer Burcak
Department of Neurosurgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Department of Neurosurgery, Mersin City Training and Research Hospital, Mersin, Turkey.
World Neurosurg. 2024 Nov;191:e664-e673. doi: 10.1016/j.wneu.2024.09.021. Epub 2024 Sep 10.
To evaluate long-term outcomes of surgical resection for congenital brain tumors (CBTs) in infants under one year of age and to identify factors related to survival.
Our retrospective study analyzed infants who underwent gross total or subtotal resection (STR) for CBTs between 2001 and 2019. Data were obtained from medical records, including demographics, clinical presentation, diagnosis, tumor characteristics, and presence of hydrocephalus. Additional factors such as preoperative and/or postoperative ventriculoperitoneal shunt placement and adjuvant chemotherapy or radiotherapy were also reviewed. Cox regression analysis was used to identify factors associated with survival.
The study included 70 patients, with median age at surgery of 198.5 days, and 28 (40%) were girls. Seizures (31.4%) and vomiting (24.3%) were the most common presenting symptoms. High-grade tumors were present in 29 (41.4%) patients. Gross total resection was achieved in 64.3% of cases, with surgical mortality rate of 7.1%. Overall survival rates at 5 and 10 years were 78% and 63%, respectively. Long-term follow-up data were available for 61 patients (87%), with median follow-up of 74.2 months. Among 45 long-term survivors, 55.5% had neurological sequelae. Factors associated with reduced survival included high-grade, preoperative hydrocephalus, larger tumor size, and ventriculoperitoneal shunt placement. The extent of resection improved survival only in low-grade tumor cases. Multivariable Cox regression analysis identified tumor grade and size as independent predictors of poor prognosis.
Surgical resection remains crucial for treating CBTs in infants under one year, yet the aggressive nature of malignant tumors results in suboptimal outcomes regarding prognosis.
