Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture and Rural Affair/Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China.
Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, 430223, China.
Fish Shellfish Immunol. 2024 Nov;154:109895. doi: 10.1016/j.fsi.2024.109895. Epub 2024 Sep 10.
The teleost kidneys are anatomically divided into head kidney and trunk kidney, each performing distinct physiological functions. Although previous research has elucidated the role of the head kidney in immune responses, there is a paucity of literature on the comparative studies of the head and trunk kidney response to bacterial infection. Therefore, an Edwardsiella ictaluri infection model of yellow catfish was constructed to investigate and compare the immune responses between the two kidney types. The findings indicated that E. ictaluri infection induced significant pathological changes in both the head and trunk kidney. Despite variances in structure, both the head and trunk kidney of yellow catfish exhibit robust immune responses following E. ictaluri infection. Unexpectedly, the up-regulation level of IgM was found to be higher in the trunk kidney compared to the head kidney. Additionally, both the IgM and IgD B cells were increased after bacterial infection. This research elucidates the parallels and distinctions in immune functions between both the head and trunk kidney in fish, enriching the immune theory of the fish kidney, and also providing a theoretical basis for the immune response of teleost kidney against bacterial infections.
硬骨鱼类的肾脏在解剖学上可分为头肾和体肾，它们分别具有不同的生理功能。尽管先前的研究已经阐明了头肾在免疫反应中的作用，但对于头肾和体肾对细菌感染的反应的比较研究还很少。因此，构建了黄颡鱼爱德华氏菌感染模型，以研究和比较两种肾脏类型的免疫反应。结果表明，E. ictaluri 感染诱导了头肾和体肾的明显病理变化。尽管结构存在差异，但黄颡鱼头肾和体肾在 E. ictaluri 感染后均表现出强烈的免疫反应。出乎意料的是，在体肾中 IgM 的上调水平高于头肾。此外，细菌感染后 IgM 和 IgD B 细胞均增加。本研究阐明了鱼类头肾和体肾在免疫功能上的平行和差异，丰富了鱼类肾脏的免疫理论，也为硬骨鱼类肾脏对细菌感染的免疫反应提供了理论基础。
