Mohabbat Majid, Barati Amir Hossein, Azarkeivan Azita, Eghbali Ehsan, Arazi Hamid
Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht,Iran.
Department of Health and Exercise Rehabilitation, Shahid Beheshti University, Tehran,Iran.
Pediatr Exerc Sci. 2024 Sep 12;37(3):260-268. doi: 10.1123/pes.2023-0197.
This study aimed to determine the acute and chronic effects of interval aerobic exercise on hepcidin, ferritin, and liver enzymes in adolescents with beta-thalassemia major.
Twenty-six beta-thalassemia major adolescents referred to the Thalassemia Clinic and Research Center were selected as study participants and randomly divided into control (n = 13) and training (n = 13) groups. Participants performed 3 sessions per week for 45 minutes in each session for 8 weeks of aerobic interval exercise with an intensity of 50% to 65% of the heart rate reserve. Blood samples were taken before, immediately after the exercise session, and 48 hours after the last training session, and liver enzymes aspartate aminotransferase, alanine aminotransferase (ALT), alkaline phosphatase (ALP), ferritin, and hepcidin were evaluated.
The results showed a decrease in aspartate aminotransferase, ALT, ALP, ferritin, and hepcidin levels due to 8 weeks of aerobic interval training (P = .14, P = .97, P = .03, P < .001, P < .001; respectively). Intergroup changes in all variables except ALT and hepcidin were significant (P < .05). Besides, acute aerobic exercise increased levels of aspartate aminotransferase, ALT, ferritin, and hepcidin (P = .04, P = .52, P < .001, P < .001; respectively), whereas ALP levels decreased (P < .001). In addition, changes in ALP and hepcidin levels were significant between the 2 groups (P = .05, P < .001; respectively).
Based on the study's results, it can be concluded that 8 weeks of aerobic interval training can decrease ferritin and hepcidin levels, but acute aerobic exercise increases them.
本研究旨在确定间歇性有氧运动对重型β地中海贫血青少年的铁调素、铁蛋白和肝酶的急性和慢性影响。
选取26名到地中海贫血诊所及研究中心就诊的重型β地中海贫血青少年作为研究对象，并随机分为对照组（n = 13）和训练组（n = 13）。参与者每周进行3次训练，每次训练45分钟，进行为期8周的有氧间歇运动，运动强度为心率储备的50%至65%。在运动前、运动结束后即刻以及最后一次训练后48小时采集血样，评估肝酶天冬氨酸转氨酶、丙氨酸转氨酶（ALT）、碱性磷酸酶（ALP）、铁蛋白和铁调素。
结果显示，经过8周的有氧间歇训练，天冬氨酸转氨酶、ALT、ALP、铁蛋白和铁调素水平均有所下降（分别为P = 0.14、P = 0.97、P = 0.03、P < 0.001、P < 0.001）。除ALT和铁调素外，所有变量的组间变化均具有显著性（P < 0.05）。此外，急性有氧运动使天冬氨酸转氨酶、ALT、铁蛋白和铁调素水平升高（分别为P = 0.04、P = 0.52、P < 0.001、P < 0.001），而ALP水平下降（P < 0.001）。另外，两组间ALP和铁调素水平的变化具有显著性（分别为P = 0.05、P < 0.001）。
根据研究结果可以得出结论，8周的有氧间歇训练可降低铁蛋白和铁调素水平，但急性有氧运动则会使其升高。
