Chander Russell J, Numbers Katya, Grainger Sarah A, Cleary Rhiagh, Mather Karen A, Kochan Nicole A, Brodaty Henry, Henry Julie D, Sachdev Perminder S
Centre for Healthy Brain Ageing (RJC, KN, RC, KAM, NAK, HB, PSS), Discipline of Psychiatry & Mental Health, School of Clinical Medicine , Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia.
Centre for Healthy Brain Ageing (RJC, KN, RC, KAM, NAK, HB, PSS), Discipline of Psychiatry & Mental Health, School of Clinical Medicine , Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia.
Am J Geriatr Psychiatry. 2025 Mar;33(3):248-259. doi: 10.1016/j.jagp.2024.08.008. Epub 2024 Aug 24.
To study general and subdomain performance in measures of social cognition in individuals with mild cognitive impairment (MCI), and dementia, and to explore associations between social cognitive and neuropsychological subdomains.
Cross-sectional study of participants from the Sydney Memory and Ageing Study (MAS).
Current data was collected in 2016-2018.
Community-dwelling older adults (n=321) aged 80 years and above, with no history of neurological or psychiatric conditions. Participants had dementia, MCI, or no cognitive impairment (NCI).
Social cognition was indexed using the Reading the Mind in the Eyes Test (RMET), the Interpersonal Reactivity Index - Perspective Taking (IRI-PT) and Empathic Concern (IRI-EC) subscales, and the Emotion Recognition Task (ERT). These subdomain scores were used to make a composite social cognition score. Apathy was measured via the Apathy Evaluation Scale (AES). Neurocognitive function was indexed using the Addenbrooke Cognitive Examination v3 (ACE-3).
Dementia was associated with poorer overall social cognitive composite performance. MCI and dementia participants performed poorer on RMET and recognition of anger, disgust and happiness on ERT. RMET and ERT disgust remained significant after controlling for relevant covariates. Dementia participants performed poorer than MCI and NCI on the IRI-PT, IRI-EC, and AES. AES remained significant after regression. RMET was correlated with ACE-3 Fluency and/or Language in all study groups.
MCI is associated with poorer scores in specific social cognitive assessments. Dementia is somewhat associated with poorer scores in informant-rated social cognition scales, though this is no longer significant after accounting for apathy.
研究轻度认知障碍（MCI）和痴呆症患者在社会认知测量中的总体及子领域表现，并探讨社会认知与神经心理子领域之间的关联。
对悉尼记忆与衰老研究（MAS）的参与者进行横断面研究。
当前数据于2016 - 2018年收集。
年龄在80岁及以上、无神经或精神疾病史的社区居住老年人（n = 321）。参与者患有痴呆症、MCI或无认知障碍（NCI）。
使用眼睛解读心智测试（RMET）、人际反应指数 - 观点采择（IRI - PT）和移情关注（IRI - EC）子量表以及情绪识别任务（ERT）对社会认知进行评分。这些子领域得分用于生成综合社会认知得分。通过冷漠评估量表（AES）测量冷漠程度。使用Addenbrooke认知检查第3版（ACE - 3）对神经认知功能进行评分。
痴呆症与总体社会认知综合表现较差相关。MCI和痴呆症参与者在RMET以及ERT中对愤怒、厌恶和快乐的识别方面表现较差。在控制相关协变量后，RMET和ERT厌恶仍具有显著性。痴呆症参与者在IRI - PT、IRI - EC和AES上的表现比MCI和NCI参与者差。回归后AES仍具有显著性。在所有研究组中，RMET与ACE - 3的流畅性和/或语言相关。
MCI与特定社会认知评估中的较差得分相关。痴呆症在 informant 评定的社会认知量表中与较差得分有一定关联，不过在考虑冷漠因素后这种关联不再显著。
