白英（Ageratina altissima）上发现的一种 Umbravirus 的全基因组序列。
Complete genome sequence of an umbravirus from white snakeroot (Ageratina altissima).
机构信息
Institute for Genomics, Biocomputing and Biotechnology, Mississippi State University, Mississippi State, MS, 39762, USA.
Department of Agricultural Science and Plant Protection, Mississippi State University, Mississippi State, MS, 39762, USA.
出版信息
Arch Virol. 2024 Sep 12;169(10):198. doi: 10.1007/s00705-024-06125-0.
Complete genome sequencing of a virus from a white snakeroot plant (Ageratina altissima (L.) King & H. Rob.) collected in the Great Smoky Mountains National Park, USA, revealed a quadricistronic organization resembling that of umbraviruses. ORFs 1 and 2 are putatively translated via a -1 ribosomal frameshift mechanism as a single polypeptide with a role in viral replication, whereas the 3'-proximal and extensively overlapping ORFs 3 and 4 code for proteins involved in long distance trafficing and cell-to-cell movement within the host. Sequence comparisons and phylogenetic analysis strongly suggested that this virus is a previously undescribed member of the genus Umbravirus (family Tombusviridae), for which the name "white snakeroot virus A" (WSVA) is proposed. In addition, we identified and initiated characterization of its possible helper virus, a putative new member of the genus Luteovirus.
从美国大烟山国家公园采集的白头婆植物（Ageratina altissima（L.）King & H. Rob.）中分离出的一种病毒的全基因组测序结果显示，其具有类似于 Umbraviruses 的四顺反子结构。ORF1 和 ORF2 通过 -1 核糖体移码机制被推定翻译为一个单一的多肽，该多肽在病毒复制中起作用，而 3'-近端和广泛重叠的 ORF3 和 ORF4 编码参与长距离运输和宿主细胞间运动的蛋白。序列比较和系统发育分析强烈表明，该病毒是 Umbravirus 属（Tombusviridae 科）的一个以前未描述的成员，建议将其命名为“白头婆病毒 A”（WSVA）。此外，我们还鉴定并开始表征其可能的辅助病毒，一种可能的新的 Luteovirus 属成员。
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