Ayene S I, Srivastava P N
Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Aug;48(2):197-205. doi: 10.1080/09553008514551191.
Radiation-induced microsomal lipid peroxidation was measured following gamma-irradiation (66-399 Gy) in the presence or absence of 2-mercaptopropionylglycine (MPG) at low and high concentrations (0.03 and 0.1 mg/ml). At high concentrations of MPG, enhancement of lipid peroxidation was observed instead of reduction. Following gamma-irradiation at 266.4 Gy, lipid peroxidation increased with increasing concentrations of MPG. The spontaneous lipid peroxidation also increased with increasing concentrations of MPG. When MPG and EDTA were added together, radioprotection was observed even at high concentrations of MPG after different doses of radiation. An increase in radioprotection with increasing concentrations of MPG in the presence of EDTA at 266.4 Gy was also observed. The exogenous supply of Fe2+ during irradiation was found to eliminate the 'threshold dose' which has to be delivered before MPG shows an 'enhancement effect'. A possible mechanism for the enhancement of radiation-induced lipid peroxidation is proposed.
在存在或不存在低浓度和高浓度（0.03和0.1mg/ml）的2-巯基丙酰甘氨酸（MPG）的情况下，对γ射线照射（66 - 399Gy）后的辐射诱导微粒体脂质过氧化进行了测量。在高浓度的MPG下，观察到脂质过氧化增强而非降低。在266.4Gy的γ射线照射后，脂质过氧化随着MPG浓度的增加而增加。自发脂质过氧化也随着MPG浓度的增加而增加。当MPG和EDTA一起添加时，即使在不同剂量辐射后高浓度的MPG下也观察到了辐射防护作用。在266.4Gy时，在存在EDTA的情况下，随着MPG浓度的增加辐射防护作用增强。发现在照射期间外源供应Fe2+可消除在MPG显示“增强效应”之前必须给予的“阈值剂量”。提出了辐射诱导脂质过氧化增强的一种可能机制。
