回复 Deora 等人在《人类基因组学》18 期，第 52 篇文章中的来信：对“EGLN1 基因中 rs479200 的 C 等位基因与印度人群 COVID-19 严重程度的关联：一项新发现”的重要见解。
Reply to correspondence by Deora et al. in Human Genomics 18, article no.: 52 (2024): critical insights on "Association of the C allele of rs479200 in the EGLN1 gene with COVID‑19 severity in Indian population: a novel finding".
机构信息
ICMR-National Institute of Malaria Research, New Delhi, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
出版信息
Hum Genomics. 2024 Sep 12;18(1):100. doi: 10.1186/s40246-024-00671-z.
Abstract
A reply to the correspondence by Deora et al.- Critical insights on "Association of the C allele of rs479200 in the EGLN1 gene with COVID‑19 severity in Indian population: a novel finding". The reply contains point-wise rebuttal to the concerns, particularly addressing the epidemiological, statistical, and mathematical issues raised by Deora et al.
摘要
回复 Deora 等人的通信——对“EGLN1 基因中 rs479200 的 C 等位基因与印度人群中 COVID-19 严重程度的关联：一项新发现”的重要见解。该回复逐点反驳了这些担忧，特别是针对 Deora 等人提出的流行病学、统计学和数学问题。
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Reply to correspondence by Deora et al. in Human Genomics 18, article no.: 52 (2024): critical insights on "Association of the C allele of rs479200 in the EGLN1 gene with COVID‑19 severity in Indian population: a novel finding".回复 Deora 等人在《人类基因组学》18 期，第 52 篇文章中的来信：对“EGLN1 基因中 rs479200 的 C 等位基因与印度人群 COVID-19 严重程度的关联：一项新发现”的重要见解。
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本文引用的文献
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Critical insights on "Association of the C allele of rs479200 in the EGLN1 gene with COVID‑19 severity in Indian population: a novel finding".关于“EGLN1 基因 rs479200 的 C 等位基因与印度人群中 COVID-19 严重程度的关联：一项新发现”的关键见解。
Hum Genomics. 2024 May 24;18(1):52. doi: 10.1186/s40246-024-00618-4.
2
Association of the C allele of rs479200 in the EGLN1 gene with COVID-19 severity in Indian population: a novel finding.EGLN1 基因 rs479200 位点 C 等位基因与印度人群 COVID-19 严重程度的关联：一项新发现。
Hum Genomics. 2024 Jan 30;18(1):7. doi: 10.1186/s40246-024-00572-1.
3
Differentiating COVID-19 Pneumonia From Acute Respiratory Distress Syndrome and High Altitude Pulmonary Edema: Therapeutic Implications.鉴别新型冠状病毒肺炎与急性呼吸窘迫综合征和高原肺水肿：治疗意义
Circulation. 2020 Jul 14;142(2):101-104. doi: 10.1161/CIRCULATIONAHA.120.047915. Epub 2020 May 5.
4
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Intensive Care Med. 2020 Jun;46(6):1099-1102. doi: 10.1007/s00134-020-06033-2. Epub 2020 Apr 14.
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Cell. 2012 Feb 3;148(3):399-408. doi: 10.1016/j.cell.2012.01.021.
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