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缺氧诱导因子在生理学和医学中的作用

Hypoxia-inducible factors in physiology and medicine.

机构信息

Vascular Program, Institute for Cell Engineering, Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

出版信息

Cell. 2012 Feb 3;148(3):399-408. doi: 10.1016/j.cell.2012.01.021.

DOI:10.1016/j.cell.2012.01.021
PMID:22304911
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3437543/
Abstract

Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining pathological consequences of HIF dysregulation in chronic diseases, and investigating potential targeting of HIFs for therapeutic purposes.

摘要

氧平衡是理解后生动物进化、发育、生理和病理生物学的基本原则。缺氧诱导因子（HIFs）是转录激活因子，作为所有后生动物物种氧平衡的主要调节剂发挥作用。目前，人们在阐明 HIF 在许多生理系统中的稳态作用、确定 HIF 失调在慢性疾病中的病理后果以及研究 HIF 作为治疗靶点的潜在靶向方面取得了快速进展。

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本文引用的文献

[1]
Corrigendum to: Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells.

Cardiovasc Res. 2021-3-21

[2]
Metabolic regulation of hematopoietic stem cells in the hypoxic niche.

Cell Stem Cell. 2011-10-4

[3]
Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication.

Circulation. 2011-9-26

[4]
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation.

Proc Natl Acad Sci U S A. 2011-9-12

[5]
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.

Cell. 2011-8-25

[6]
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.

Oncogene. 2011-8-22

[7]
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.

Cell. 2011-5-27

[8]
Chronic lung allograft rejection and airway microvasculature: is HIF-1 the missing link?

J Clin Invest. 2011-5-23

[9]
Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection.

J Clin Invest. 2011-5-23

[10]
Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds.

J Mol Med (Berl). 2011-4-16

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