唾液皮质醇和α-淀粉酶作为评估个体化音乐干预痴呆症患者的应激标志物：可行性和初步分析。
Salivary cortisol and alpha-amylase as stress markers to evaluate an individualized music intervention for people with dementia: feasibility and pilot analyses.
机构信息
Department for Counseling and Clinical Intervention, Friedrich-Schiller-University Jena, Jena, Germany.
Institute of Psychology and Education, Ulm University, Ulm, Germany.
出版信息
BMC Res Notes. 2024 Sep 12;17(1):258. doi: 10.1186/s13104-024-06904-7.
OBJECTIVES
We investigated salivary biomarkers of stress, more specifically, cortisol and alpha-amylase, to evaluate effects of individualized music listening (IML) in people with dementia.
METHOD
Participants were N = 64 nursing home residents with dementia (mean = 83.53 ± 7.71 years, 68.8% female). Participants were randomly assigned to either listening to their favorite music every other day for a period of six weeks (intervention), or standard care (control). Using the Saliva Children`s Swab (SCS), saliva was collected before, after, and 20 min after IML sessions at the beginning and end of the intervention period for the analysis of salivary alpha-amylase and cortisol.
RESULTS
Using the SCS was feasible in people with dementia. Nevertheless, there was no effect of IML on salivary stress markers.
DISCUSSION
Although using SCS was feasible, active patient engagement is required. Future studies need to corroborate findings in larger samples.
TRIAL REGISTRATION
German Clinical Trials Register: DRKS00015641, ISRCTN registry: ISRCTN59052178.
目的
我们研究了唾液生物标志物（即皮质醇和α-淀粉酶），以评估个体化音乐聆听（IML）对痴呆患者的影响。
方法
参与者为 64 名居住在养老院的痴呆症患者（平均年龄=83.53±7.71 岁，68.8%为女性）。参与者被随机分配到每隔一天听他们喜欢的音乐 6 周（干预组）或标准护理（对照组）。在干预期开始和结束时，使用唾液儿童拭子（SCS）在 IML 前后以及 20 分钟后采集唾液，以分析唾液中的α-淀粉酶和皮质醇。
结果
使用 SCS 在痴呆患者中是可行的。然而，IML 对唾液应激标志物没有影响。
讨论
尽管使用 SCS 是可行的，但需要积极的患者参与。未来的研究需要在更大的样本中证实这些发现。
试验注册
德国临床试验注册中心：DRKS00015641，ISRCTN 注册中心：ISRCTN59052178。
Zotero 插件