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赛马和马术运动中的基因兴奋剂:现状与未来展望。

Gene doping in horse racing and equine sports: Current landscape and future perspectives.

作者信息

Puchalska Maria, Witkowska-Piłaszewicz Olga

机构信息

Department of Large Animals Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.

出版信息

Equine Vet J. 2025 Mar;57(2):312-324. doi: 10.1111/evj.14418. Epub 2024 Sep 12.

DOI:10.1111/evj.14418
PMID:39267222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11807943/
Abstract

Gene doping, the use of gene therapy or genetic manipulation to enhance athletic performance, has emerged as a potential threat to the integrity and welfare of equine sports, such as horse racing and equestrian sports. This review aims to provide an overview of gene doping in horses, including the underlying technologies, potential applications, detection methods, ethical concerns and future perspectives. By understanding the current landscape of gene doping in horses, stakeholders can work together to develop strategies to safeguard the integrity of equine sports.

摘要

基因兴奋剂,即利用基因治疗或基因操纵来提高运动成绩,已成为对赛马和马术运动等马类运动的诚信和福利的潜在威胁。本综述旨在概述马类运动中的基因兴奋剂问题,包括相关基础技术、潜在应用、检测方法、伦理问题和未来展望。通过了解马类运动中基因兴奋剂的现状,相关利益者可以共同制定策略,以维护马类运动的诚信。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b84/11807943/5a553c7ce599/EVJ-57-312-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b84/11807943/d5a865be2bc1/EVJ-57-312-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b84/11807943/b9055dfd3351/EVJ-57-312-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b84/11807943/5a553c7ce599/EVJ-57-312-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b84/11807943/d5a865be2bc1/EVJ-57-312-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b84/11807943/b9055dfd3351/EVJ-57-312-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b84/11807943/5a553c7ce599/EVJ-57-312-g003.jpg

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Looking Back, Moving Forward: Lipid Nanoparticles as a Promising Frontier in Gene Delivery.回首往昔,展望未来:脂质纳米颗粒作为基因递送领域的前沿希望
ACS Pharmacol Transl Sci. 2023 Oct 24;6(11):1561-1573. doi: 10.1021/acsptsci.3c00185. eCollection 2023 Nov 10.
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Current State of Human Gene Therapy: Approved Products and Vectors.人类基因治疗的现状:获批产品与载体
Pharmaceuticals (Basel). 2023 Oct 5;16(10):1416. doi: 10.3390/ph16101416.
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The Emerging Role of Hypoxic Training for the Equine Athlete.低氧训练在马属动物运动员中的新作用
Animals (Basel). 2023 Sep 3;13(17):2799. doi: 10.3390/ani13172799.
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A Review of Recent Progress in Drug Doping and Gene Doping Control Analysis.药物滥用和基因兴奋剂检测分析的最新进展综述。
Molecules. 2023 Jul 18;28(14):5483. doi: 10.3390/molecules28145483.
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