Department of Clinical Sciences, Lund University, Lund, Sweden.
Lund Stem Cell Center, Lund University, Lund, Sweden.
Transpl Int. 2024 Aug 29;37:13215. doi: 10.3389/ti.2024.13215. eCollection 2024.
Solid organ transplantation has progressed rapidly over the decades from the first experimental procedures to its role in the modern era as an established treatment for end-stage organ disease. Solid organ transplantation including liver, kidney, pancreas, heart, and lung transplantation, is the definitive option for many patients, but despite the advances that have been made, there are still significant challenges in meeting the demand for viable donor grafts. Furthermore, post-operatively, the recipient faces several hurdles, including poor early outcomes like primary graft dysfunction and acute and chronic forms of graft rejection. In an effort to address these issues, innovations in organ engineering and treatment have been developed. This review covers efforts made to expand the donor pool including bioengineering techniques and the use of graft perfusion. It also covers modifications and treatments that have been trialed, in addition to research efforts in both abdominal organs and thoracic organs. Overall, this article discusses recent innovations in machine perfusion and organ bioengineering with the aim of improving and increasing the quality of donor organs.
几十年来，实体器官移植从最初的实验性手术发展到现代，已成为治疗终末期器官疾病的一种成熟治疗方法。包括肝、肾、胰腺、心脏和肺移植在内的实体器官移植是许多患者的最终选择，但尽管取得了这些进展，仍然存在着巨大的挑战，难以满足对可行供体移植物的需求。此外，移植术后，受者还面临着包括原发性移植物功能障碍和急性及慢性移植物排斥等不良早期结局在内的多个障碍。为了解决这些问题，器官工程和治疗方面的创新已经得到了发展。这篇综述涵盖了为扩大供者群体所做的努力，包括生物工程技术和移植物灌注的应用。它还涵盖了已尝试的改良和治疗方法，以及腹部器官和胸部器官的研究工作。总的来说，本文讨论了机器灌注和器官生物工程方面的最新创新，旨在提高和增加供体器官的质量。
