Madhvapathy Surabhi R, Wang Jiao-Jing, Wang Heling, Patel Manish, Chang Anthony, Zheng Xin, Huang Yonggang, Zhang Zheng J, Gallon Lorenzo, Rogers John A
Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA 60208.
Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA 60208.
Science. 2023 Sep 8;381(6662):1105-1112. doi: 10.1126/science.adh7726. Epub 2023 Sep 7.
Early-stage organ transplant rejection can be difficult to detect. Percutaneous biopsies occur infrequently and are risky, and measuring biomarker levels in blood can lead to false-negative and -positive outcomes. We developed an implantable bioelectronic system capable of continuous, real-time, long-term monitoring of the local temperature and thermal conductivity of a kidney for detecting inflammatory processes associated with graft rejection, as demonstrated in rat models. The system detects ultradian rhythms, disruption of the circadian cycle, and/or a rise in kidney temperature. These provide warning signs of acute kidney transplant rejection that precede changes in blood serum creatinine/urea nitrogen by 2 to 3 weeks and approximately 3 days for cases of discontinued and absent administration of immunosuppressive therapy, respectively.
早期器官移植排斥反应可能难以检测。经皮活检不常进行且有风险，而检测血液中的生物标志物水平可能导致假阴性和假阳性结果。我们开发了一种可植入生物电子系统，能够连续、实时、长期监测肾脏的局部温度和热导率，以检测与移植排斥相关的炎症过程，大鼠模型已证明了这一点。该系统可检测到超日节律、昼夜节律的破坏和/或肾脏温度升高。这些都提供了急性肾移植排斥反应的警示信号，在血清肌酐/尿素氮变化之前，分别有2至3周以及在停止和未给予免疫抑制治疗的情况下约3天的预警期。
