First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Cardiovascular Diseases, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China.
Front Public Health. 2024 Aug 29;12:1418134. doi: 10.3389/fpubh.2024.1418134. eCollection 2024.
Per- and polyfluoroalkyl substance (PFAS) exposure and cardiovascular disease are controversial. We aimed to assess the association between serum PFAS exposure and cardiovascular health (CVH) in U.S. adults.
We analyzed serum PFAS concentration data of U.S. adults reported in the National Health and Nutrition Examination Survey (NHANES) study (2005-2018). We employed two weighted logistic regression models and a restricted cubic spline (RCS) to examine the association between each PFAS and impaired CVH (defined as moderate and low CVH). Quantile g-computation (Qgcomp) and weighted quantile sum (WQS) analysis were used to estimate the effects of mixed exposures to PFASs on impaired CVH.
PFAS were associated with an increased risk of impaired CVH (OR: 1.40, 95% CI: 1.09, 1.80; OR: 1.44, 95% CI: 1.10, 1.88; OR: 1.62, 95% CI: 1.25, 2.11). PFOA and PFOS exhibited nonlinear relationships with impaired CVH. Significant interactions were observed for impaired CVH between race/ethnicity and PFHxS ( = 0.02), marital status and PFOA ( = 0.03), and both marital status and race/ethnicity with PFOS ( = 0.01 and p = 0.02, respectively). Analysis via WQS and Qgcomp revealed that the mixture of PFAS was positively associated with an increased risk of impaired CVH.
PFNA, PFOA, and PFOS exposure are associated with an increased risk of impaired CVH in U.S. adults. Race/ethnicity and marital status may influence CVH. Reducing PFAS exposure could alleviate the burden of disease associated with impaired CVH.
全氟和多氟烷基物质（PFAS）暴露与心血管疾病之间存在争议。我们旨在评估美国成年人血清 PFAS 暴露与心血管健康（CVH）之间的关系。
我们分析了美国国家健康和营养检查调查（NHANES）研究（2005-2018 年）中报告的美国成年人的血清 PFAS 浓度数据。我们采用了两种加权逻辑回归模型和限制立方样条（RCS）来研究每种 PFAS 与 CVH 受损之间的关系（定义为 CVH 中度和低度受损）。定量分位数组（Qgcomp）和加权分位数和（WQS）分析用于估计混合暴露于 PFAS 对 CVH 受损的影响。
PFAS 与 CVH 受损的风险增加相关（OR：1.40，95%CI：1.09，1.80；OR：1.44，95%CI：1.10，1.88；OR：1.62，95%CI：1.25，2.11）。PFOA 和 PFOS 与 CVH 受损呈非线性关系。在种族/民族和 PFHxS 之间（ = 0.02）、婚姻状况和 PFOA 之间（ = 0.03），以及婚姻状况和种族/民族之间（ = 0.01 和 p = 0.02，分别）观察到 CVH 受损的显著交互作用。通过 WQS 和 Qgcomp 进行的分析表明，PFAS 混合物与 CVH 受损风险增加呈正相关。
PFNA、PFOA 和 PFOS 暴露与美国成年人 CVH 受损的风险增加有关。种族/民族和婚姻状况可能会影响 CVH。减少 PFAS 暴露可能会减轻与 CVH 受损相关的疾病负担。
