Teng Xiaodong, Zhao Ming, Lai Maode
Department of Pathology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2016 Jan;45(1):36-44. doi: 10.3785/j.issn.1008-9292.2016.01.06.
Pulmonary neuroendocrine tumors are common in pathological practice and its pathological classification and histological grading are not exactly the same as that of those in the digestive tract and pancreas. In 2015 edition of World Health Organization classification, pulmonary neuroendocrine tumors are classified as carcinoid tumors (including typical carcinoid and atypical carcinoid), small cell lung carcinoma, large cell neuroendocrine carcinoma, and precursor lesion diffuse idiopathic neuroendocrine cell hyperplasia; each category has distinctive morphological and immunohistochemical features. The morphologic features including growth patterns and cytological appearances are keys for the diagnosis of neuroendocrine tumor, and immunohistochemical findings are also critical for its diagnosis. Furthermore, the diagnostic criteria vary for different types of specimen. In this article, we present a concise review and summary of the update of clinicopathological characterizations of pulmonary neuroendocrine tumor, with an emphasis on its diagnostic criteria and differential diagnosis.
肺神经内分泌肿瘤在病理实践中很常见，其病理分类和组织学分级与消化道和胰腺的并不完全相同。在2015年版世界卫生组织分类中，肺神经内分泌肿瘤被分为类癌肿瘤（包括典型类癌和非典型类癌）、小细胞肺癌、大细胞神经内分泌癌以及前驱病变弥漫性特发性神经内分泌细胞增生；每一类都有独特的形态学和免疫组化特征。包括生长方式和细胞学表现在内的形态学特征是神经内分泌肿瘤诊断的关键，免疫组化结果对其诊断也至关重要。此外，不同类型标本的诊断标准也有所不同。在本文中，我们对肺神经内分泌肿瘤临床病理特征的更新进行了简要回顾和总结，重点在于其诊断标准和鉴别诊断。
