Huang Ke, Yu Li, Lu Dingci, Zhu Ziyi, Shu Min, Ma Zhaowu
School of Basic Medicine, Yangtze University, Health Science Center, Yangtze University, Jingzhou, Hubei, China.
Front Oncol. 2024 Aug 29;14:1437698. doi: 10.3389/fonc.2024.1437698. eCollection 2024.
As global population ageing accelerates, cancer emerges as a predominant cause of mortality. Long non-coding RNAs (lncRNAs) play crucial roles in cancer cell growth and death, given their involvement in regulating downstream gene expression levels and numerous cellular processes. Cell death, especially non-apoptotic regulated cell death (RCD), such as ferroptosis, pyroptosis and necroptosis, significantly impacts cancer proliferation, invasion and metastasis. Understanding the interplay between lncRNAs and the diverse forms of cell death in cancer is imperative. Modulating lncRNA expression can regulate cancer onset and progression, offering promising therapeutic avenues. This review discusses the mechanisms by which lncRNAs modulate non-apoptotic RCDs in cancer, highlighting their potential as biomarkers for various cancer types. Elucidating the role of lncRNAs in cell death pathways provides valuable insights for personalised cancer interventions.
随着全球人口老龄化加速，癌症成为主要的死亡原因。长链非编码RNA（lncRNAs）在癌细胞的生长和死亡中发挥着关键作用，因为它们参与调节下游基因表达水平和众多细胞过程。细胞死亡，尤其是非凋亡性调节性细胞死亡（RCD），如铁死亡、焦亡和坏死性凋亡，对癌症的增殖、侵袭和转移有显著影响。了解lncRNAs与癌症中多种细胞死亡形式之间的相互作用至关重要。调节lncRNA表达可调控癌症的发生和发展，提供了有前景的治疗途径。本综述讨论了lncRNAs调节癌症中非凋亡性RCD的机制，强调了它们作为各种癌症类型生物标志物的潜力。阐明lncRNAs在细胞死亡途径中的作用为个性化癌症干预提供了有价值的见解。
