疾病中与铁死亡相关的长链非编码RNA

Zhou Wu, Thiery Jean Paul

Medical College, Jiaxing University, Jiaxing, 314001, China.

Biosyngen Pte Ltd, Singapore, 536671, Singapore.

BMC Biol. 2025 Jun 6;23(1):158. doi: 10.1186/s12915-025-02268-x.

Ferroptosis is a form of regulated cell death (RCD) caused by the accumulation of intracellular iron and lipids and is involved in many pathological processes, including neurodegenerative and cardiovascular diseases, and cancer. Long non-coding RNAs (lncRNAs), RNA molecules exceeding 200 nt in length that do not possess protein coding function can interfere with ferroptosis by binding ferroptosis-related miRNAs or proteins. Recently, ferroptosis-related lncRNAs (FRlncRNAs) have been identified in cancer and non-malignant disease models, including inprediction of drug resistance, intra-tumoral immune infiltration, metabolic reprogramming and mutation landscape. Here, we review FRlncRNAs in cancer and non-malignant diseases, from prognosis to treatment.

铁死亡是一种由细胞内铁和脂质积累引起的程序性细胞死亡（RCD）形式，参与许多病理过程，包括神经退行性疾病、心血管疾病和癌症。长链非编码RNA（lncRNA）是长度超过200个核苷酸且不具有蛋白质编码功能的RNA分子，可通过与铁死亡相关的微小RNA（miRNA）或蛋白质结合来干扰铁死亡。最近，在癌症和非恶性疾病模型中已鉴定出铁死亡相关的lncRNA（FRlncRNA），包括在耐药性预测、肿瘤内免疫浸润、代谢重编程和突变图谱方面。在此，我们综述了FRlncRNA在癌症和非恶性疾病中从预后到治疗的研究情况。