Vaidya Yash P, Hagmann Theodore D, Shumway Sara
Department of Cardiothoracic Surgery, University of Minnesota, Minneapolis, MN 55455, United States.
J Surg Case Rep. 2024 Sep 11;2024(9):rjae578. doi: 10.1093/jscr/rjae578. eCollection 2024 Sep.
Factor VIII deficiency, also known as hemophilia A, is the most common inherited bleeding disorder. Deficiency of Factor VIII results in dysfunction of platelet aggregation due to decreased activation of Factor X to Xa. We present the case of a 68-year-old male with mild hemophilia A (Factor VIII activity, 16%) who underwent a three-vessel coronary artery bypass graft and patent foramen ovale repair, with no increased bleeding utilizing a recombinant Factor VIII (kogenate) preoperative bolus and continuous infusion. His postoperative course was complicated by a sternal wound dehiscence requiring washout, sternal wire removal and omental flap coverage on postoperative Day 21. However, he required no postoperative blood transfusions.
八因子缺乏症，也称为甲型血友病，是最常见的遗传性出血性疾病。八因子缺乏导致由于因子X向Xa的激活减少而引起血小板聚集功能障碍。我们报告一例68岁男性轻度甲型血友病（八因子活性为16%）患者，该患者接受了三支冠状动脉搭桥术和卵圆孔未闭修复术，术前使用重组八因子（科跃奇）推注和持续输注，未出现出血增加情况。他的术后病程因胸骨伤口裂开而复杂化，在术后第21天需要进行冲洗、拆除胸骨钢丝和网膜瓣覆盖。然而，他术后无需输血。
