Zhang Meilan, Zheng Zhaokuan, Wang Shouliang, Liu Ruihan, Zhang Mengli, Guo Zhiyun, Wang Hao, Tan Weige
The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou 511400, Guangdong, China.
Department of Orthopedics, Affiliated Huadu Hospital, Southern Medical University (People's Hospital of HuaduDistrict), Guangzhou 510810, Guangdong, China.
Cancer Drug Resist. 2024 Aug 20;7:30. doi: 10.20517/cdr.2024.62. eCollection 2024.
MicroRNAs (miRNAs) are small non-coding RNAs comprising 19-24 nucleotides that indirectly control gene expression. In contrast to other non-coding RNAs (ncRNAs), circular RNAs (circRNAs) are defined by their covalently closed loops, forming covalent bonds between the 3' and 5' ends. circRNAs regulate gene expression by interacting with miRNAs at transcriptional or post-transcriptional levels. Accordingly, circRNAs and miRNAs control many biological events related to cancer, including cell proliferation, metabolism, cell cycle, and apoptosis. Both circRNAs and miRNAs are involved in the pathogenesis of diseases, such as breast cancer. This review focuses on the latest discoveries on dysregulated circRNAs and miRNAs related to breast cancer, highlighting their potential as biomarkers for clinical diagnosis, prognosis, and chemotherapy response.
微小RNA（miRNA）是由19 - 24个核苷酸组成的小型非编码RNA，它们间接控制基因表达。与其他非编码RNA（ncRNA）不同，环状RNA（circRNA）由其共价闭合环定义，在3'和5'末端之间形成共价键。circRNA通过在转录或转录后水平与miRNA相互作用来调节基因表达。因此，circRNA和miRNA控制许多与癌症相关的生物学事件，包括细胞增殖、代谢、细胞周期和凋亡。circRNA和miRNA都参与疾病的发病机制，如乳腺癌。本综述重点关注与乳腺癌相关的失调circRNA和miRNA的最新发现，突出它们作为临床诊断、预后和化疗反应生物标志物的潜力。
