Gerard Louise, Gillet Jean-Pierre
Laboratory of Molecular Cancer Biology, URPhyM, NARILIS, University of Namur, Namur 5000, Belgium.
Cancer Drug Resist. 2024 Aug 7;7:29. doi: 10.20517/cdr.2024.56. eCollection 2024.
The gene encodes several isoforms, including two transporters (i.e., ABCB5FL, ABCB5β) and several soluble proteins, such as ABCB5α which has been hypothesized to have a regulatory function. ABCB5FL is a full ABC transporter and is expressed in the testis and prostate, whereas ABCB5β is an atypical half-transporter with a ubiquitous expression pattern. ABCB5β has been shown to mark cancer stem cells in several cancer types. In addition, ABCB5β and ABCB5FL have been shown to play a role in tumorigenesis and multidrug resistance. However, ABCB5β shares its entire protein sequence with ABCB5FL, making them difficult to distinguish. It cannot be excluded that some biological effects described for one transporter may be mediated by the other isoform. Therefore, it is difficult to interpret the available data and some controversies remain regarding their function in cancer cells. In this review, we discuss the data collected on ABCB5 isoforms over the last 20 years and propose a common ground on which we can build further to unravel the pathophysiological roles of ABCB5 transporters.
该基因编码多种异构体，包括两种转运蛋白（即ABCB5FL、ABCB5β）和几种可溶性蛋白，如据推测具有调节功能的ABCB5α。ABCB5FL是一种完整的ABC转运蛋白，在睾丸和前列腺中表达，而ABCB5β是一种具有普遍表达模式的非典型半转运蛋白。ABCB5β已被证明可标记多种癌症类型中的癌症干细胞。此外，ABCB5β和ABCB5FL已被证明在肿瘤发生和多药耐药中起作用。然而，ABCB5β与ABCB5FL共享其整个蛋白质序列，使得它们难以区分。不能排除针对一种转运蛋白描述的某些生物学效应可能由另一种异构体介导。因此，很难解释现有数据，并且关于它们在癌细胞中的功能仍存在一些争议。在本综述中，我们讨论了过去20年中收集的关于ABCB5异构体的数据，并提出了一个共同基础，以便我们能够在此基础上进一步开展研究，以阐明ABCB5转运蛋白的病理生理作用。
