解读ABCB5在正常细胞和癌细胞中的作用。
Deciphering the roles of ABCB5 in normal and cancer cells.
作者信息
Duvivier Laurent, Gillet Jean-Pierre
机构信息
Laboratory of Molecular Cancer Biology, URPhyM, NARILIS, Faculty of Medicine, University of Namur, Namur, Belgium.
Laboratory of Molecular Cancer Biology, URPhyM, NARILIS, Faculty of Medicine, University of Namur, Namur, Belgium.
出版信息
Trends Cancer. 2022 Oct;8(10):795-798. doi: 10.1016/j.trecan.2022.07.001. Epub 2022 Jul 27.
ABCB5 encodes a full transporter (ABCB5FL) and a half transporter (ABCB5β), which is unique in the ATP binding cassette (ABC) transporter superfamily. We discuss the roles of both isoforms in undifferentiated slow-cycling cells, multidrug resistance, and tumorigenesis, and their regulation pathways.
ABCB5编码一个完整转运蛋白（ABCB5FL）和一个半转运蛋白（ABCB5β），这在ATP结合盒（ABC）转运蛋白超家族中是独一无二的。我们讨论了这两种异构体在未分化的慢循环细胞、多药耐药性和肿瘤发生中的作用及其调控途径。
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