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医护人员在遭受锐器伤和接触生物体液后HIV血清转化的发生率。

The Prevalence of HIV Seroconversion in Healthcare Workers Following Sharp Injuries and Exposure to Biofluids.

作者信息

Pineda-Ramirez Jorge Luis, Sierra-Diaz Erick, Zavala-Sánchez Eugenio Vladimir, Zarate-Leal Guadalupe, Cisneros-García Diana Lorena, Hernández-Muñoz Eduardo Alfonso, Guerrero-García Jose de Jesus, Ramirez-De Arellano Adrian

机构信息

Preventive Medicine, Instituto Mexicano del Seguro Social, Guadalajara, MEX.

Epidemiology and Public Health, Instituto Mexicano del Seguro Social, Guadalajara, MEX.

出版信息

Cureus. 2024 Aug 13;16(8):e66773. doi: 10.7759/cureus.66773. eCollection 2024 Aug.

Abstract

Background and objective Workplace accidents (WPAs) are a common problem worldwide. They are often considered a public health concern due to the potential transmission of infections such as HIV, hepatitis B, and hepatitis C through sharp devices or direct exposure to biofluids. Post-exposure prophylaxis (PEP) has demonstrated effectiveness in such instances, especially immediately after exposure. The present study aimed to report the prevalence rate of HIV seroconversion following such exposure among healthcare workers (HCWs). Methods We conducted a cross-sectional study involving a database analysis of cases from 2015 to 2024. Central tendency measures were used to describe population characteristics, and rates were calculated using standard methods. Results A total of 514 HCWs were included in the study. The prevalence of WPAs was 13 per 100 HCWs. Regarding WPAs related to HIV exposure, the prevalence was 0.9 per 100 HCWs, with 0% seroconversion thanks to timely PEP. Conclusions WPAs related to HIV exposure are a serious issue for public health systems worldwide. Although protocols are available and no seroconversion cases were reported in the present study, PEP is not always accessible in several settings, increasing the risk of seroconversion. International public policy measures should be uniformly implemented to provide faster access to prophylaxis, educate the personnel, raise awareness about bloodborne diseases, and reduce excessive red tape.

摘要

背景与目的 工作场所事故(WPAs)是全球范围内的常见问题。由于诸如艾滋病毒、乙型肝炎和丙型肝炎等感染可能通过锐器或直接接触生物体液传播,这些事故常被视为公共卫生问题。暴露后预防(PEP)已在此类情况下显示出有效性,尤其是在暴露后立即进行预防。本研究旨在报告医护人员(HCWs)在此类暴露后艾滋病毒血清转化的患病率。方法 我们进行了一项横断面研究,对2015年至2024年的病例进行数据库分析。采用集中趋势指标描述人群特征,并使用标准方法计算发病率。结果 共有514名医护人员纳入本研究。工作场所事故的患病率为每100名医护人员中有13例。关于与艾滋病毒暴露相关的工作场所事故,患病率为每100名医护人员中有0.9例,由于及时进行暴露后预防,血清转化率为0%。结论 与艾滋病毒暴露相关的工作场所事故是全球公共卫生系统面临的一个严重问题。尽管有相关方案,且本研究中未报告血清转化病例,但在一些情况下暴露后预防并非总能获得,这增加了血清转化的风险。应统一实施国际公共政策措施,以便更快地提供预防措施,对人员进行教育,提高对血源性病原体的认识,并减少过多的繁文缛节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2147/11392009/93daea892bb4/cureus-0016-00000066773-i01.jpg

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