Silva Vixey, Bindernagel Richard G, Cheng Melissa, Miller Richard
Dermatology, HCA Healthcare/University of South Florida (USF) Morsani College of Medicine: Largo Medical Center Program, Largo, USA.
Dermatology, Western University of Health Sciences, Pomona, USA.
Cureus. 2024 Aug 13;16(8):e66797. doi: 10.7759/cureus.66797. eCollection 2024 Aug.
Nonkeratinizing squamous cell carcinoma (NKSCC) of the sinonasal tract is a rare malignancy that infrequently presents with cutaneous extension. This case describes an unusual instance of extensive facial skin involvement in an elderly male with multiple comorbidities, diagnosed with a biopsy-proven NKSCC. The tumor was p16 positive, suggesting an HPV-related etiology. This case emphasizes the critical role of dermatologists in the early diagnosis and multidisciplinary management of such aggressive tumors. It highlights the necessity of including NKSCC in the differential diagnosis of destructive facial tumors. Dermatologists should remain vigilant for rare presentations and employ early biopsy and histopathological examinations to facilitate prompt multidisciplinary intervention. Recognizing p16 positivity can indicate a human papillomavirus (HPV)-related etiology, potentially influencing prognosis and management strategies.
鼻窦非角化性鳞状细胞癌（NKSCC）是一种罕见的恶性肿瘤，很少出现皮肤侵犯。本病例描述了一名患有多种合并症的老年男性面部皮肤广泛受累的不寻常情况，经活检证实为NKSCC。肿瘤p16阳性，提示与人乳头瘤病毒（HPV）相关的病因。本病例强调了皮肤科医生在这类侵袭性肿瘤的早期诊断和多学科管理中的关键作用。它突出了将NKSCC纳入面部破坏性肿瘤鉴别诊断的必要性。皮肤科医生应警惕罕见表现，并采用早期活检和组织病理学检查，以便迅速进行多学科干预。认识到p16阳性可提示与人乳头瘤病毒（HPV）相关的病因，可能影响预后和治疗策略。
