Chernock Rebecca D
Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8118, St Louis, MO, USA.
Head Neck Pathol. 2012 Jul;6 Suppl 1(Suppl 1):S41-7. doi: 10.1007/s12105-012-0373-4. Epub 2012 Jul 3.
Morphologic assessment is one of the most basic tools that pathologists use to classify tumors. Human papillomavirus (HPV)-related squamous cell carcinoma of the oropharynx has unique morphologic features that can be readily recognized under the microscope. Yet, these features are not widely recognized or uniformly reported. In our practice, we group oropharyngeal squamous cell carcinomas into 'nonkeratinizing', 'nonkeratinizing with maturation', and 'keratinizing' histologic types. The 'nonkeratinizing' type has a very strong association with HPV, while the 'keratinizing' type has a weaker association with the virus. 'Nonkeratinizing with maturation' is intermediate but much more closely related to the 'nonkeratinizing' type. This classification system parallels that of sinonasal and nasopharyngeal squamous cell carcinomas where nonkeratinizing squamous cell carcinomas are widely recognized histologic variants. This review will discuss this classification system and its utility in routine clinical practice.
形态学评估是病理学家用于肿瘤分类的最基本工具之一。人乳头瘤病毒（HPV）相关的口咽鳞状细胞癌具有独特的形态学特征，在显微镜下很容易识别。然而，这些特征并未得到广泛认可或统一报告。在我们的实践中，我们将口咽鳞状细胞癌分为“非角化型”、“伴成熟的非角化型”和“角化型”组织学类型。“非角化型”与HPV的关联非常强，而“角化型”与该病毒的关联较弱。“伴成熟的非角化型”处于中间状态，但与“非角化型”关系更为密切。这种分类系统与鼻窦和鼻咽鳞状细胞癌的分类系统相似，在鼻窦和鼻咽鳞状细胞癌中，非角化鳞状细胞癌是广泛认可的组织学变体。本综述将讨论这种分类系统及其在常规临床实践中的应用。
