N S Veda Samhitha, Dhanabal Divya, Sundaram Sandhya, V Pavithra, Balasubramanian Subalakshmi
Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Cureus. 2024 Aug 13;16(8):e66783. doi: 10.7759/cureus.66783. eCollection 2024 Aug.
Introduction Cervical cancer ranks among the top gynaecological cancers worldwide. It is linked to lower socioeconomic status and high human papillomavirus (HPV) prevalence. This is a series of six cervical carcinoma cases analysed from 2021 to 2023 at our tertiary care centre to identify rare subtypes of cervical carcinoma. We document rare subtypes, which include glassy cell carcinoma, small cell neuroendocrine carcinoma, papillary squamous-transitional variant, basaloid squamous cell carcinoma and serous carcinoma of the uterine cervix. Immunohistochemistry (IHC) was helpful in confirmation of the subtypes and in diagnosing HPV-associated cases. Materials and methods This case series comprises six cases, including rare subtypes and variants of cervical carcinoma histopathologically diagnosed by the Department of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India, between 2021 and 2023. The demographic profile and patient details were obtained from the hospital information system and archival case files after obtaining informed consent from the patients. The H&E and relevant IHC slides along with histopathology reports of the included cases were analysed and studied. Results This series includes six cases of rare subtypes of cervical carcinoma, comprising glassy cell carcinoma, small cell neuroendocrine carcinoma, papillary squamous-transitional variant, basaloid squamous cell carcinoma (SCC), and serous carcinoma. Each subtype displays distinct clinicopathological features, emphasizing the need for specific diagnostic and treatment approaches, which are crucial in improving patient survival. Conclusion Six rare subtypes and variants of cervical carcinoma have been discussed in this case series, after correlating with histopathology reports and clinical and radiological findings. Understanding the histopathological characteristics of these rarer subtypes is essential for accurate diagnosis and timely intervention. This series highlights the importance of comprehensive screening strategies, early diagnosis and awareness of rarer subtypes and variants of cervical carcinoma among healthcare professionals. These factors can tailor therapeutic options and improve patient outcomes.
引言
宫颈癌是全球最常见的妇科癌症之一。它与较低的社会经济地位和高人类乳头瘤病毒（HPV）感染率有关。本文分析了2021年至2023年期间在我们的三级护理中心的6例宫颈癌病例，以确定宫颈癌的罕见亚型。我们记录了罕见亚型，包括玻璃样细胞癌、小细胞神经内分泌癌、乳头状鳞状-移行变体、基底样鳞状细胞癌和子宫颈浆液性癌。免疫组织化学（IHC）有助于确认亚型并诊断HPV相关病例。
材料与方法
本病例系列包括6例病例，包括2021年至2023年期间在印度钦奈的斯里·拉马钱德拉高等教育和研究机构病理科经组织病理学诊断的宫颈癌罕见亚型和变体。在获得患者知情同意后，从医院信息系统和档案病例文件中获取人口统计学资料和患者详细信息。对纳入病例的苏木精-伊红（H&E）和相关免疫组织化学切片以及组织病理学报告进行了分析和研究。
结果
本系列包括6例宫颈癌罕见亚型病例，包括玻璃样细胞癌、小细胞神经内分泌癌、乳头状鳞状-移行变体、基底样鳞状细胞癌（SCC）和浆液性癌。每个亚型都表现出独特的临床病理特征，强调了采取特定诊断和治疗方法的必要性，这对提高患者生存率至关重要。
结论
本病例系列在与组织病理学报告以及临床和放射学结果相关联后，讨论了6种罕见的宫颈癌亚型和变体。了解这些较罕见亚型的组织病理学特征对于准确诊断和及时干预至关重要。本系列强调了全面筛查策略、早期诊断以及医疗专业人员对宫颈癌较罕见亚型和变体的认识的重要性。这些因素可以调整治疗方案并改善患者预后。
